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USE OF VIP FOR THE PREPARATION OF A MEDICAMENT FOR TREATING THE ENDOTOXIC SHOCK IN MAMMALSCM Patents

Method for the treatment of endotoxic shock in mammals. The use of vasoactive intestinal peptide (VIP) and peptide activating hypofissiary adenylate cyclase (PACAP) is described in the treatment of endotoxic shock in mammals. These substances inhibit the production of tumor necrosis factor (TNF) and interleukin 6 (IL-6).

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.1002542.A1
Fecha publicacion
24/05/2000
Anio publicacion
2000

En detalle

Reivindicaciones

1. A method for the treatment of endotoxic shock in mammals characterised in that it comprises administration of an effective amount of an agent that inhibits the production of tumor necrosis factor (TNF) in a pharmaceutically acceptable vehicle. 2. A method for the treatment of endotoxic shock in mammals according to claim 1, characterised in that the inhibitory agent is the vasoactive intestinal peptide (VIP) or a fragment thereofor an analogue derived therefrom. 3. A method for the treatment of endotoxic shock in mammals according to claim 1, characterised in that the inhibitory agent is the peptide activating hypofissiary adenylate cyclase (PACAP) or a fragment thereof or an analogue derived therefrom. 4. A method for the treatment of endotoxic shock in mammals characterised in that it comprises the administration of an effective amount of an agent that inhibits the production of interleukin 6 (IL-6) in a pharmaceutically acceptable vehicle. 5. A method for the treatment of endotoxic shock in mammals according to claim 4, characterised in that the inhibitory agent is the vasoactive intestinal peptide (VIP) or a fragment thereof or an analogue derived therefrom. 6. A method for the treatment of endotoxic shock in mammals, according to claim 4, characterised in that the inhibitory agent is the peptide activating hypofissiary adenylate cyclase (PACAP) or a fragment thereof or an analogue derived therefrom.

Etiquetas

Inventores
Perez Gomariz RosaPerez Gomariz, Rosa, Facultad de CiencLeceta Martinez JavierBiologia CelularLeceta Martinez, Javier, Facultad de CDelgado Mora MarioMartinez Mora CarmenDelgado Mora, Mario, Facultad de CiencMartinez Mora, Carmen, Facultad de CieRosa Perez GomarizJavier Leceta MartinezMario Delgado MoraCarmen Martinez MoraDelgado Mora, MarioPerez Gomariz, RosaLeceta Martinez, JavierMartinez Mora, CarmenPerez Gomariz Rosa MariaMartinez Javier LecetaDelgado MarioMartinez Carmen
Solicitantes
Universidad Complutense de Madrid
Clasificacion ipc
A61K 38/ 00 A IA61K 38/ 22 A IA61K 45/ 00 A IA61P 37/ 00 A IA61P 43/ 00 A IC12P 21/ 04 A I
Clasificacion cpc
4C084/AA024C084/AA174C084/BA014C084/BA024C084/BA194C084/ZB051A61K37/02A61K45/00A61P37/00A61P43/00&111435/69.5435/69.52514/1.4514/2.1514/9.7530/300
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