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ECTEINASCIDIN ANALOGUES, THEIR USE IN THE PREPARATION OF A MEDICAMENT FOR TREATMENT OF CANCER AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDSCM Patents

Derivatives of ecteinascidin 736 of general formula (I) wherein the groups R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4 </SUB>and R<SUB>5 </SUB>are each independently selected from the group consisting of H, OH, OR', SH, SR', SOR', SO<SUB>2</SUB>R', C(-O)R', C(-O)OR', NO<SUB>2</SUB>, NH<SUB>2</SUB>, NHR', N(R')<SUB>2</SUB>, NHC(O)R', CN, halogen, -O, substituted or unsubstituted C<SUB>1</SUB>-C<SUB>25 </SUB>alkyl, substituted or unsubstituted C<SUB>2</SUB>-C<SUB>18 </SUB>alkenyl, substituted or unsubstituted C<SUB>2</SUB>-C<SUB>18 </SUB>alkynyl, substituted or unsubstituted arly, substituted or unsubstituted heterocyclic; wherein X is independently selected of OR', CN, (-O), or H; wherein each of the R' groups is independently selected from the group consisting of H, OH, NO<SUB>2</SUB>, NH<SUB>2</SUB>, SH, CN, halogen, -O, C(-O)H, C(-O)CH<SUB>3</SUB>, CO<SUB>2</SUB>H, substituted or unsubstituted C<SUB>1</SUB>-C<SUB>25 </SUB>alkyl, substituted or unsubstituted C<SUB>1</SUB>-C<SUB>18 </SUB>alkenyl, substituted or unsubstituted C<SUB>2</SUB>-C<SUB>18 </SUB>alkynyl, substituted or unsubstituted aryl; wherein m is 0, 1 or 2; and wherein n is 0, 1, 2, 3, or 4, and their use as antitumoral agent.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.1414828.A1
Fecha publicacion
06/05/2004
Anio publicacion
2004

En detalle

Reivindicaciones

1. A compound of formula: <img class="EMIRef" id="460046602-ib0037" /> <img class="EMIRef" id="460046602-ib0038" /> <img class="EMIRef" id="460046602-ib0039" /> <img class="EMIRef" id="460046602-ib0040" /> <img class="EMIRef" id="460046602-ib0041" /> <img class="EMIRef" id="460046602-ib0042" /> <img class="EMIRef" id="460046602-ib0043" /> <img class="EMIRef" id="460046602-ib0044" /> <img class="EMIRef" id="460046602-ib0045" /> <img class="EMIRef" id="460046602-ib0046" /> <img class="EMIRef" id="460046602-ib0047" /> <img class="EMIRef" id="460046602-ib0048" /> <img class="EMIRef" id="460046602-ib0049" /> <img class="EMIRef" id="460046602-ib0050" /> <img class="EMIRef" id="460046602-ib0051" /> <img class="EMIRef" id="460046602-ib0052" /> <img class="EMIRef" id="460046602-ib0053" /> <img class="EMIRef" id="460046602-ib0054" /> <img class="EMIRef" id="460046602-ib0055" /> <img class="EMIRef" id="460046602-ib0056" /> <img class="EMIRef" id="460046602-ib0057" /> <img class="EMIRef" id="460046602-ib0058" /> <img class="EMIRef" id="460046602-ib0059" /> or <img class="EMIRef" id="460046602-ib0060" /> 2. A compound according to claim 1 of formula (27): <img class="EMIRef" id="460046602-ib0061" /> 3. A compound according to claim 1 of formula (30): <img class="EMIRef" id="460046602-ib0062" /> 4. A compound according to claim 1 of formula (31): <img class="EMIRef" id="460046602-ib0063" /> 5. A compound according to claim 1 of formula (33): <img class="EMIRef" id="460046602-ib0064" /> 6. A compound according to claim 1 of formula: <img class="EMIRef" id="460046602-ib0065" /> 7. A compound according to claim 1 of formula (2): <img class="EMIRef" id="460046602-ib0066" /> 8. A compound according to claim 1 of formula (5): <img class="EMIRef" id="460046602-ib0067" /> 9. A compound according to claim 1 of formula (6): <img class="EMIRef" id="460046602-ib0068" /> 10. A compound according to claim 1 of formula (8): <img class="EMIRef" id="460046602-ib0069" /> 11. A pharmaceutical composition which contains a compound according to any preceding claim together with a pharmaceutically acceptable diluent. 12. The use of a compound according to any of claims 1 to 10 in the preparation of a medicament for treatment of cancer.

Etiquetas

Inventores
Martinez ValentinMartinez, ValentinGallego, PilarGallego PilarCuevas, CarmenCuevas CarmenMunt, SimonMunt SimonManzanares IgnacioManzanares, IgnacioSimon MuntValentin MartinezIgnacio ManzanaresCarmen CuevasPilar GallegoIgnacio Martinez Valentin CuevMartinez Valentin,Cuevas Carmen,Gallego Pilar,Munt Simon,Manzanares IgnacioMARTINEZ ValentinGALLEGO PilarCUEVAS CarmenMUNT SimonMANZANARES IgnacioМАРТИНЕС Валентин(ES)Martines ValentinГАЛЬЕГО Пилар(ES)Gal Ego PilarКУЭВАС Кармен(ES)Kuehvas KarmenMant SajmonМАНТ Саймон(ES)МАНСАНАРЕС Игнасио(ES)Mansanares Ignasio
Solicitantes
Pharma Mar S.A.Farma Mar S.A.Фарма Мар, СА
Clasificacion ipc
A61K 31/ 4995 A IA61P 35/ 00 A IC07D 515/ 22 A IA61K 31/ 438 A IA61K 31/ 4985 A IA01N 43/ 58 A IA01N 43/ 60 A IA61K 31/ 495 A IA61K 31/ 498 A IA61K 31/ 50 A IC07D 487/ 00 A IC07D 491/ 00 A IC07D 498/ 22 A IC07D 513/ 00 A I
Clasificacion cpc
4C086/AA024C086/AA034C086/CB314C086/MA024C086/MA054C086/NA144C086/ZB26A61K31/4995A61P35/00C07D515/224C086/AA014C086/BC944C086/MA014C086/MA04514/249540/468
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