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Antitumoral 5,8-dihydrodiazaanthracenesCM Patents

Azaanthracene-triones of the formula: <CHEM> (in which: R<1>, R<2>, R<4> and R<5> are the same or are different and each is a hydrogen atom or a lower alkyl group; R<3> is a hydrogen atom, a lower alkyl group, a phenyl group or an amino-substituted phenyl gro up; and X is a -CH-, =N- or -NH-, whereby the ring containing the group X is a benzene, pyridine or dihydropyridene ring> have antitumoral activity.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.0574195.A1
Fecha publicacion
15/12/1993
Anio publicacion
1993

En detalle

Reivindicaciones

1. Azaanthracene-triones of the formula: <img class="EMIRef" id="418593703-ib0009" /> in which: R¹, R², R⁴ and R⁵ are the same or are different and each is a hydrogen atom or a lower alkyl group; R³ is a hydrogen atom, a lower alkyl group, a phenyl group or an amino-substituted phenyl group; and X is a -CH-, =N- or -NH-, whereby the ring containing the group X is a benzene, pyridine or dihydropyridene ring. 2. Compounds as claimed in claim 1 as specifically disclosed in any of the examples herein. 3. A pharmaceutical composition comprising a compound as claimed in claim 1 or claim 2 in association with a pharmaceutical carrier or diluent. 4. The use of a compound as claimed in claim 1 in the manufacture of an antitumoral composition.

Etiquetas

Inventores
Avendano, CarmenAvendano CarmenAlonso Miguel AAlonso, Miguel AEspada, ModestaEspada ModestaGarcia-Gravalos DoloresGarcia-Gravalos, DoloresMenendez, Jose CMenendez Jose COcana BlancaOcana, BlancaPerez, Jose M.Perez Jose MCarmen AvendanoAlonso Miguel AngelMiguel Angel AlonsoModesta EspadaDolores Garcia-GravalosJose Carlos MenendezMenendez Jose CarlosBlanca OcanaJose Maria PerezPerez Jose MariaAlonso, Miguel A.Menendez, Jose C.Avendano Carmen Universidad CoAvendano, Carmen Universidad Complutense de MadridAlonso Miguel A Universidad CoAlonso, Miguel A Universidad Complutense de MadridEspada Modesta Universidad ComEspada, Modesta Universidad Complutense de MadridGarcia-Gravalos, Dolores Pharma Mar S.A.Garcia-Gravalos Dolores PharmaMenendez Jose C Universidad CoMenendez, Jose C Universidad Complutense de MadridOcana Blanca Universidad ComplOcana, Blanca Universidad Complutense de MadridPerez, Jose M. Universidad Complutense de MadridPerez Jose M Universidad ComplKarumen AbendanoMigeru Anjieru AronsoModesuta EsupadaDororesu Garushia GurabarosuHose Karurosu MenendetsuBuranka OkanaHose Maria PeretsuDolores Garcia GravalosGravalos Dolores GarciaAlonso MiguelMiguel AlonsoJose C MenendezJose M. PerezAvendanoCarmenAlonsoMiguel A.Mendendez Jose CEspadaModestaGarcia-GravalosDoloresMendendezJose C.OcanaBlancaPerezJose M.
Solicitantes
Universidad Complutense de MadridYuniberushidado Komupurutense de MadoritsudoYuniberushidado Komupurutense
Clasificacion ipc
A61K 31/ 435 A IA61K 31/ 473 A IA61K 31/ 4745 A IA61K 31/ 47 A IA61P 35/ 00 A IC07D 221/ 08 A IC07D 471/ 04 A I
Clasificacion cpc
4C065/AA044C065/AA194C065/BB094C065/CC094C065/DD024C065/EE024C065/HH014C065/HH024C065/HH064C065/JJ014C065/JJ044C065/KK014C065/KK024C065/KK064C065/LL044C065/PP014C065/PP034C086/AA014C086/AA024C086/AA034C086/AA104C086/BC274C086/CB094C086/MA014C086/MA044C086/NA144C086/ZB264C086/ZB27A61K31/435A61K31/47A61K31/473A61K31/4745A61P35/00C07D221/08C07D471/04&112C07D471/04&112Z514/292514/297546/103546/81
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