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AN IN VITRO METHOD FOR DETECTING CANCERCM Patents

The present invention relates to an in vitro method for detecting cancer in a subject, for predicting the clinical outcome of a subject suffering from cancer, or for monitoring the treatment of a subject suffering from cancer, based on the tumoral carbohydrate Ca10 (Ca10) levels measured in a biofluid sample isolated from the subject.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.4556909.A1
Fecha publicacion
21/05/2025
Anio publicacion
2025
Numero solicitud
EP20230383183

En detalle

Reivindicaciones

1. An in vitro method for detecting cancer in a subject, comprising: (a) quantifying the tumoral carbohydrate Ca10 (Ca10) levels in a biological sample isolated from the subject; and (b) comparing the Ca10 levels obtained in step (a) with a control level, Wherein if the Ca10 levels in the subject are increased with respect to the control levels, then the subject suffers from cancer. 2. An in vitro method for predicting the clinical outcome of a subject suffering from cancer, or for monitoring the treatment of a subject suffering from cancer, comprising (a) quantifying the tumoral carbohydrate Ca10 (Ca10) levels in a biological sample isolated from the subject; and (b) comparing the Ca10 levels obtained in step (a) with a control level, Wherein if the Ca10 levels in the subject are increased with respect to the control level, then - the clinical outcome of the subject is negative and either the subject is going to suffer from metastasis or the tumoral mass is going to increase; or - the treatment is not effective. 3. The method according to claim 1 or 2, wherein the cancer is a carcinoma or an adenocarcinoma. 4. The method according to any one of claims 1 to 3, wherein the cancer is prostate cancer, cervix cancer, breast cancer, pancreatic cancer, lung cancer, gastric cancer, endometrial cancer, skin cancer, thyroid cancer, bladder cancer, ovarian cancer, lever cancer, esophageal cancer, or colorectal cancer. 5. The method according to any one of claims 1 to 4, wherein the biological sample is blood, serum, plasma, pleural liquid, bronchioalveolar liquid, peritoneal liquid, faeces, urine, sputum or tissue biopsy specimens. 6. Use of a kit for detecting cancer in vitro, or for predicting in vitro the clinical outcome of a subject suffering from cancer, or for monitoring in vitro the treatment of a subject suffering from cancer, wherein the kit comprises elements for quantifying the Ca10 levels in a biological sample of a subject. 7. Use of a kit for detecting cancer in vitro, or for predicting in vitro the clinical outcome of a subject suffering from cancer, or for monitoring in vitro the treatment of a subject suffering from cancer, according to claim 6, wherein the cancer is a carcinoma or an adenocarcinoma. 8. Use of a kit for detecting cancer in vitro, or for predicting in vitro the clinical outcome of a subject suffering from cancer, or for monitoring in vitro the treatment of a subject suffering from cancer, according to claim 6 or 7, wherein the cancer is prostate cancer, cervix cancer, breast cancer, pancreatic cancer, lung cancer, gastric cancer, endometrial cancer, skin cancer, thyroid cancer, bladder cancer, ovarian cancer, lever cancer, esophageal cancer, or colorectal cancer. 9. Use of a kit for detecting cancer in vitro, or for predicting in vitro the clinical outcome of a subject suffering from cancer, or for monitoring in vitro the treatment of a subject suffering from cancer, according to any one of claims 6 to 8, wherein the biological sample is blood, serum or plasma pleural liquid, bronchioalveolar liquid, peritoneal liquid, faeces, urine, sputum or tissue biopsy specimens 10. Use of a kit for detecting cancer in vitro, or for predicting in vitro the clinical outcome of a subject suffering from cancer, or for monitoring in vitro the treatment of a subject suffering from cancer, according to any one of claims 6 to 9, wherein the elements are antibodies, or a fragment thereof, peptides or aptamers, all of them with affinity for Ca10.

Etiquetas

Inventores
J·L·苏比萨·加里多-莱斯塔什J·I·图德拉·加西亚L·M·莫尔托·德尔加多M·费尔南德斯·阿克罗M·维纽埃拉·马丁F·J·卡尼亚达·维西奈I·卡洛格拉亚基O·帕洛马雷斯·格拉西亚L·马丁·德·拉·克鲁斯A·安吉丽娜·克伦西亚斯Subiza Garrido-Lestache, José LuisSubiza Garrido-Lestache José LuisTudela Garcia, José IgnacioTudela Garcia José IgnacioMoltó Delgado, Luis ManuelMoltó Delgado Luis ManuelFernández Arquero, MiguelFernández Arquero MiguelViñuela Martín, MarcosViñuela Martín MarcosCañada Vicinay, Francisco JavierCañada Vicinay Francisco JavierKalograiaki, IoannaKalograiaki IoannaPalomares Gracia OscarPalomares Gracia, OscarMartín de la Cruz LeticiaMartín de la Cruz, LeticiaAngelina Querencias, AlbaAngelina Querencias AlbaSUBIZA GARRIDO-LESTACHE, José LuisTUDELA GARCIA, José IgnacioMOLTÓ DELGADO, Luis ManuelFERNÁNDEZ ARQUERO, MiguelVIÑUELA MARTÍN, MarcosCAÑADA VICINAY, Francisco JavierKALOGRAIAKI, IoannaPALOMARES GRACIA, OscarMARTÍN de la CRUZ, LeticiaANGELINA QUERENCIAS, Alba
Solicitantes
尹姆诺泰克公司马德里圣卡洛斯临床医院研究基金会Inmunotek S.L.Fundación para la Investigación Biomédica del Hospital Clínico San Carlos
Clasificacion ipc
G01N 33/ 575 A IG01N 33/ 574 A I
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