Logo
About usInnovation CMChallengesEuropaEntrepreneurshipR&D&I SearchAgentsEventsReports
en
CRAMBESCIDIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMCM Patents

The separation that instructed through FABMS, already from the extracts of sponge wild cabbage sponge Crambe crambe of the Mediterranean, obtaining 2 kinds maidenly has per unit low-content ingredient crambescidin 834 (7)s of a chloro spermidine, 818 (8)s and 4 kinds are not maiden as the per unit low-content ingredient crambescidin673 (9) of derivation of spermidine, 687 (10)s, 657 (11)s and 13,14,15-isocrambescidin 657 (12) and known crambescidins (1-5) and ptilomycalin A (6). Analyze (seen Fig. 4-9) through the spectrum data, has explained their structure. In examining middle warmer claming parallelly to L1210 rat's leukaemia cell, crambescidins 834 (7)s, the cytotoxicity that 818 (8)s and 657 (11)s demonstrate is 5 times that of known crambescidin 816 (1)s. Spermidine unit or spermidine derivation per unit crambescidins demonstrates the antibacterial activity to rhodotorula.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.0975606.A1
Fecha publicacion
02/02/2000
Anio publicacion
2000

En detalle

Reivindicaciones

CLAIMS: 1. 1. Substantially pure Crambescidin 834. 2. 2. Substantially pure Crambescidin 818. 3. 3. Substantially pure Crambescidin 673. 4. 4. Substantially pure Crambescidin 687. 5. 5. Substantially pure Crambescidin 657. 6. 6. Substantially pure 13,14,15 Isocrambescidin 657. 7. 7. Substantially pure methyl Crambescidin 657. 8. 8. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 834 and a pharmaceutically acceptable carrier, diluent or excipient. 9. 9. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 818 and a pharmaceutically acceptable carrier, diluent or excipient. 10. 10. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 673 and a pharmaceutically acceptable carrier, diluent or excipient. 11. 11. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 687 and a pharmaceutically acceptable carrier, diluent or excipient. 12. 12. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient. 13. 13. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as 13,14,15 Isocrambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient. 14. 14. A pharmaceutical or veterinary composition comprising an effective antitumor amount of the substantially pure compound designated herein as methyl Crambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient. 15. 15. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 834 and a pharmaceutically acceptable carrier, diluent or excipient. 16. 16. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 818 and a pharmaceutically acceptable carrier, diluent or excipient. 17. 17. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 673 and a pharmaceutically acceptable carrier, diluent or excipient. 18. 18. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 687 and a pharmaceutically acceptable carrier, diluent or excipient. 19. 19. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Crambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient. 20. 20. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as 13,14,15 Isocrambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient. 21. 21. The use for the manufacture of a medicament for the therapeutic or prophylactic treatment of a patient suffering from a mammalian tumor, of an effective antitumor amount of the substantially pure compound designated herein as Methyl Crambescidin 657 and a pharmaceutically acceptable carrier, diluent or excipient.

Etiquetas

Inventores
Shi Jian-GongJian-Gong ShiFurong SunSun FurongRinehart Kenneth LKenneth L. RinehartSun, FurongShi, Jian-GongRinehart, Kenneth L.Jiangong ShiShi JiangongRinehart K LK. L. RinehartShi, JianShi JianRinehart, Kenneth, L.Rinehart, Kenneth L시,쟌-공선,퍼롱리네하트,케네쓰,엘.Rinehart Kenneth LloydRinehart, Kenneth LloydRinehart Kenneth L.RinehartShi Jiang-GongKenneth L.ShiJiang-GongSunFurong
Solicitantes
Pharma Mar S.A.Ernest V LinekLinek Ernest V파르마 마르.에스.에이리네크, 이미스트, 브이
Clasificacion ipc
A01N 43/ 90 A IA61K 31/ 527 A IA61P 35/ 00 A IC07D 491/ 22 A I
Clasificacion cpc
4C050/AA044C050/BB044C050/CC074C050/DD024C050/EE034C050/FF034C050/GG024C050/GG034C050/HH014C086/AA014C086/AA024C086/AA034C086/CB224C086/GA164C086/MA014C086/MA044C086/NA144C086/ZB264C086/ZB274C086/ZC50A61K31/527A61P35/00C07D491/22514/257514/267544/231
Logo

Innovation CM
Challenges
Europa
Entrepreneurship
R&D&I Search
Agents
Events
Reports
About us
Contact
Give us your opinion
Cookies
Legal notice
Privacy

© Copyright Espacio Madrileño de Investigación e Innovación 2026