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METABOLITES OF ECTEINASCIDINE-743, PHARMACEUTICAL COMPOSITION BASED ON THEIR BASE AND METHODS FOR TREATMENTCM Patents

<div notation="docdba" type="abstract" xml:base="/api/emi/section/d0091e70-a923-4bf5-a3ac-c0d2bb7009c9/image" xml:lang="en"><p>FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention relates to new compounds that are metabolites of ecteinascidine of the following structural formulas: ETM-305 , ETM-204 and ETM-775 . These compounds are strong antitumor agents. Invention relates also to pharmaceutical compositions based on these compounds and to methods for treatment of malignant tumors. Invention provides preparing new antitumor agents. EFFECT: improved preparing method and method for treatment, valuable medicinal properties of compounds. 10 cl, 2 tbl, 23 dwg</p></div>

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.1077698.A1
Fecha publicacion
28/02/2001
Anio publicacion
2001

En detalle

Reivindicaciones

1. ETM-305, having the following structure: <img class="EMIRef" id="454104533-ib0006" /> 2. ETM-204, having the following structure: <img class="EMIRef" id="454104533-ib0007" /> 3. ETM-775 having the following structure: <img class="EMIRef" id="454104533-ib0008" /> 4. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian leukemia in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 5. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian leukemia in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 6. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian lung carcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 7. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian lung carcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 8. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian colon adenocarcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-30S to said patient in unit dosage form. 9. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian colon adenocarcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 10. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian malignant melanoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 11. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian malignant melanoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 12. A pharmaceutical composition comprising ETM-305 according to claim 1 and a pharmaceutically acceptable carrier, diluent or excipient. 13. A pharmaceutical composition comprising ETM-775 according to claim 3 and a pharmaceutically acceptable carrier, diluent or excipient.

Etiquetas

Inventores
Rinehart, Kenneth, L.Rinehart Kenneth LMorales Jose JMorales, Jose, J.Reid JoelReid, JoelReymundo IsabelReymundo, IsabelFloriano PabloFloriano, PabloGarcia Gravalos, LolaGarcia Gravalos LolaKenneth L. RinehartJose J. MoralesJoel ReidIsabel ReymundoPablo FlorianoLola Garcia GravalosGravalos Lola GarciaRINEHART KennethMORALES JoseREID JoelREYMUNDO IsabelFLORINO PabloGARCIA GRAVALOS LolaGravalos Lola GRinehart KennethMorales JoseFlorino PabloKenneth LloydLloyd KennethReymundo Isabel CuestaIsabel Cuesta ReymundoLola Gravalos GarciaGarcia Lola GravalosRinehart, Kenneth L.Morales, Jose J.Reymundo Cuesto, IsabelReymundo Cuesto IsabelReymundo Cuesta IsabelRinehart Kenneth L.Morales Jose J.Isabel ReymindoReymindo IsabelGravalos Lola G.Rinehart Kenneth L Morales JosRinehart Kenneth L.,Morales Jose J.,Reid Joel,Reymindo Isabel,Floriano Pablo,Gravalos Lola G.K.L. RinehartRinehart K LMorales J JJ.J. MoralesJ. Reid Et AlAl J Reid EtReid JJ. ReidRinehart@Kenneth LloydRinehart Kenneth LloydMorales@Jose JReid@JoelReymundo Cuesta@IsabelFloriano@PabloGarcia Gravalos@LolaRinehart, L.Rinehart LMorales, J.Morales JMorales, Jose JRinehart, Kenneth L린하트케네쓰엘.모랄스조제이제이.레이드조엘레이먼도이사벨플로리아노파블로가르시아그라발로스로라Reymundo, Isabel CuestaРАЙНХАРТ Кеннет Л(US)Rajnkhart Kennet LМОРАЛЕС Хосе Х(US)Morales Khose KhРЕЙД Джоел(US)Rejd DzhoelRejmundo IsabelРЕЙМУНДО Исабель(ES)ФЛОРИАНО Пабло(ES)Garsija Gravalos LolaГАРСИЯ ГРАВАЛОС Лола(ES)Kenneth Lloyd RinehartIsabel Reymundo CuestaCuesta Isabel Reymundo
Solicitantes
Pharma Mar S.A.Pharma Mar S A An Illinois CorPharama Mar S.A.Pharma Mar, SA, An Illinois CorporationThe Board of Trustees of the University of IllinoisUniv Illinois
Clasificacion ipc
A61K 31/ 357 A IA61K 31/ 36 A IA61K 31/ 39 A IA61K 31/ 472 A IA61K 31/ 4747 A IA61K 31/ 47 A IA61K 31/ 4995 A IA61K 35/ 02 A IA61P 35/ 00 A IC07D 217/ 10 A IC07D 217/ 24 A IC07D 317/ 44 A IC07D 317/ 64 A IC07D 317/ 66 A IC07D 327/ 02 A IC07D 411/ 14 A IC07D 491/ 14 A IC07D 497/ 22 A IC07D 515/ 22 A IA61K 31/ 4985 A IA61P 35/ 02 A IC07C 41/ 09 A IC07C 43/ 04 A IC07D 217/ 04 A IC07D 317/ 68 A IC07D 317/ 52 A IC12Q 1/ 26 A IC07D 317/ 46 A IC07D 221/ 18 A I
Clasificacion cpc
4C022/EA014C086/AA014C086/AA024C086/AA034C086/BA134C086/BC304C086/CB224C086/MA014C086/MA044C086/NA144C086/ZB264C086/ZB274C087/AA014C087/AA024C087/BB044C087/NA144C087/ZB264C087/ZB27A61K31/357A61K31/36A61K31/47A61K31/472A61K31/4995A61K35/02A61P35/00C07D217/10C07D317/64C07D515/224B063/QA054B063/QA204B063/QQ984B063/QR024B063/QR044B063/QR574B063/QR654B063/QS024B063/QS174B063/QX104C086/MA024C086/MA05A61P35/02C12Q1/26544/230546/139549/436568/584514/278514/307514/464546/17546/38435/25514/250544/233
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