Logo
About usInnovation CMChallengesEuropa2iEntrepreneurshipR&D&I SearchAgentsEventsReports
en
COMPOUNDS USED TO TREAT ALCOHOLISMCM Patents

Índice de la ficha

Updated at
24/07/2026
Numero publicacion
WO.03004453.A1
Fecha publicacion
16/01/2003
Numero solicitud
WO2002ES00323
Fecha presentacion
01/07/2002

En detalle

Resumen

The invention relates to a novel compound, N,N'-bis (3-aminopropyl) cyclohexane-1,4-diamine, having formula (I) which is prepared by hydrogenation using a Raney nickel catalyst of N,N'-bis (2-cyanoethyl)-cyclohexane-1,4-diamine, the latter being prepared by reaction between 1,4-cyclohexanediamine and acrylonitrile. The oral administration of the tetramethanesulphonate monohydrate of (I) to genetically alcoholic mice (from the UChB strain from the University of Chili) causes a significant reduction in the consumption of alcohol. The activity of said compound continues for a certain amount of time following the treatment period. Moreover, there is practically zero disulfiram-type adverse effect, which is advantageous given the disagreeable aspect of using some antialcoholic agents, such as calcium cyanamide and said disulfiram. In this way, the inventive compounds can be used to prepare medicaments for the therapeutic and/or prophylactic treatment of alcoholism in mammals, including humans.

Etiquetas

Inventores
Bilbeny Lojo NorbertoGarcia Madrid HernanFont Arellano Maria Belen
Solicitantes
Garbil Pharma Investigacion ChBilbeny Lojo NorbertoGarcia Madrid HernanFont Arellano Maria BelenGarbil Pharma Investigacion Chile Ltda
Clasificacion ipc
A61K 31/ 132 A IA61K 31/ 16 A IA61P 25/ 32 A IC07B 61/ 00 A IC07C 209/ 48 A IC07C 211/ 36 A IC07C 233/ 08 A I
Clasificacion cpc
514/554514/659564/448564/453564/454564/461564/462
Logo

Innovation CM
Challenges
Europa2i
Entrepreneurship
R&D&I Search
Agents
Events
Reports
About us
Contact
Give us your opinion
Cookies
Legal notice
Privacy

© Copyright Espacio Madrileño de Investigación e Innovación 2026