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Resumen

The use of a compound possessing functional antagonist properties at the NMDA receptor complex through a specific action at the associated strychnine-insensitive glycine site to improve cognition in normal humans and to treat cognitive deficits resulting from chronic neuronal degeneration, acute brain injury, hypoxia, or other neurological disorders is provided. In particular, the compounds possessing functional antagonist properties comprise 1-aminocyclopropanecarboxylic acid, and its pharmaceutically acceptable esters, salts, and acid addition salts or 7-chlorokynurenic acid, and its pharmaceutically acceptable esters, amides, salts, ethers, and acid addition salts.

Reivindicaciones

1. Use of a compound having the formula: <img class="EMIRef" id="588191205-ib0003" /> where A is -CO<2>H, or a pharmaceutically acceptable ester, amide, or salt thereof; and X is -NR<1>R<2> or a pharmaceutically acceptable acid addition salt thereof, and where R<1> and R<2> are independently selected from hydrogen or lower alkyl, optionally substituted with halogen, hydroxyl, alkoxy, oxo, mercapto, aryl, or amino, or R<1> and R<2> together with the nitrogen to which they are attached form a substituted 5-membered or 6-membered heterocycle which can also contain another heteroatom selected from oxygen, sulfur or nitrogen, which is a partial agonist for the strychnine-insensitive glycine site of the NMDA receptor due to a specific interaction with the receptor, and which acts as a functional antagonist of the strychnine-insensitive glycine site of the NMDA receptor complex by reducing or antagonizing the effects of glutamate or NMDA, in the preparation of a medicament for either improving or enhancing memory or cognition. 2. Use of a compound as claimed in claim 1, characterised in that the compound possessing partial agonist properties is selected from 1-aminocyclopropanecarboxylic acid or a pharmaceutically-acceptable salt, amide, and ester thereof. 3. Use of a compound as claimed in claim 2, characterised in that the compound possessing partial agonist properties is 1-aminocyclopropanecarboxylic acid.

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