madrid2i

Resumen

<div notation="docdba" type="abstract" xml:lang="en"><p>FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention relates to new compounds that are metabolites of ecteinascidine of the following structural formulas: ETM-305 , ETM-204 and ETM-775 . These compounds are strong antitumor agents. Invention relates also to pharmaceutical compositions based on these compounds and to methods for treatment of malignant tumors. Invention provides preparing new antitumor agents. EFFECT: improved preparing method and method for treatment, valuable medicinal properties of compounds. 10 cl, 2 tbl, 23 dwg</p></div>

Reivindicaciones

1. ETM-305, having the following structure: <img class="EMIRef" id="454104533-ib0006" /> 2. ETM-204, having the following structure: <img class="EMIRef" id="454104533-ib0007" /> 3. ETM-775 having the following structure: <img class="EMIRef" id="454104533-ib0008" /> 4. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian leukemia in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 5. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian leukemia in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 6. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian lung carcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 7. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian lung carcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 8. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian colon adenocarcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-30S to said patient in unit dosage form. 9. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian colon adenocarcinoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 10. The use of ETM-305 according to claim 1 in the preparation of a medicament for the treament of mammalian malignant melanoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-305 to said patient in unit dosage form. 11. The use of ETM-775 according to claim 3 in the preparation of a medicament for the treament of mammalian malignant melanoma in patients in need of such treatment, said method comprising administering an effective amount of ETM-775 to said patient in unit dosage form. 12. A pharmaceutical composition comprising ETM-305 according to claim 1 and a pharmaceutically acceptable carrier, diluent or excipient. 13. A pharmaceutical composition comprising ETM-775 according to claim 3 and a pharmaceutically acceptable carrier, diluent or excipient.

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