Resumen
The present invention refers to a cell suspension comprising expanded autologous or allogeneic mesenchymal stromal cells derived from the bone marrow of a human subject, wherein said MSCs are suspended in the plasma fraction obtained from the peripheral blood from a patient or subject to be treated with the cell suspension, for use in the treatment or amelioration of a disease with cerebral impaired glucose metabolism, wherein said cell suspension is administered to the patient or subject via intrathecal (through an intrathecal administration), in particular by lumbar puncture.
Reivindicaciones
1. Claims 1. A cell suspension comprising expanded autologous or allogeneic mesenchymal stromal cells (MSCs) derived from the bone marrow of a human subject, wherein said MSCs are suspended in the plasma fraction obtained from the peripheral blood from a patient or subject to be treated with the cell suspension, for use in the treatment or amelioration of a disease with cerebral impaired glucose metabolism, wherein said cell suspension is administered to the patient via intrathecal (through an intrathecal administration in the cerebrospinal fluid of the subarachnoid space), in particular by lumbar puncture. 2. The cell suspension for use according to claim 1, wherein the disease with cerebral impaired glucose metabolism is cerebral stroke or the neurological sequelae after a hemorrhagic stroke, or a neurodegenerative disease selected from the list consisting of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, Friedreich's ataxia, frontotemporal lobar degeneration, and dementia with Lewy bodies. 3. The cell suspension for use according to claim 1, wherein the disease with cerebral impaired glucose metabolism is Alzheimer's disease. 4. The cell suspension for use according to any of claims 1 to 3, wherein the MSCs are autologous. 5. The cell suspension for use according to any of the precedent claims, wherein the cell suspension comprises from about 30 x 10<5>to about 30 x 10<7>, more preferably from about 1 x 10<6>to about 100 x 10<6>, still more preferably about 30 x 10<6>expanded MSCs obtained from bone marrow. 6. A syringe or a plurality of syringes comprising a cell suspension as defined in any of claims 1 to 5, for use in the treatment or amelioration of a disease with cerebral impaired glucose metabolism, wherein said cell suspension is administered to the patient via intrathecal (through an intrathecal administration), in particular by lumbar puncture. 7. The syringe(s) according to claim 6, wherein the disease with cerebral impaired glucose metabolism is a neurodegenerative disease selected from the list consisting of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, Friedreich's ataxia, frontotemporal lobar degeneration, and dementia with Lewy bodies. 8. The syringe(s) according to claim 6, wherein the disease with cerebral impaired glucose metabolism is Alzheimer's disease. 9. The cell suspension for use according to any one of claims 1-5 or the syringe(s) for use according to any one of claims 6 to 8, wherein said suspension is provided as a single dose or as multiples dosages.
