Reivindicaciones
1. Claims 1. A composition comprising polymeric micelles as a nanocarrier and one or more molecules of a phthalocyanine as a payload, wherein the phthalocyanine is of the formula I : <img class="EMIRef" id="509797054-imgf000045-0001" /> in which (a) M represents a metal or metalloid atom, (b) Ri , R<2>, R<3>, R t. R5, R-6, R-7 and Rs are independently selected from the group consisting of hydrogen, halogen, -R9, -OR9, -SR9, or -NR9R10, in which R9 and Rio independently represent hydrogen, C i i ^alky!, or a phenyl group optionally substituted by one or more Rn groups independently selected from the group consisting of C<1-12>alkyl, halogen, OR 12. -SR12, and -NR 12R ! ·, in which R12 and R13 each independently represent hydrogen or G ^a!ky , or one or more pairs of Ri and R2, R3 and R t, R5 and Rc, and R? and Rx are attached to adjacent carbon atoms and together form, together with the ring to which they are attached, an aromatic fused ring system, and (c) Ra represents hydrogen or a group <img class="EMIRef" id="509797054-imgf000045-0002" /> and Rb represents hydrogen or a group <img class="EMIRef" id="509797054-imgf000046-0001" /> wherein A and B independently represent a single bond, -CH<2>- or -(C=0)-, and Ria, R2a, R-3a, R ib, R211 and Rsb independently represent hydrogen, G-iealkyl, -C≡CH, -COOH, -NH2, -CH2NH2, -SC≡N. -CH<2>SC≡N or -[OCH<2>CH<2>]n-OR, in which R represents hydrogen or Chalky! and n represents an integer of from 1 to 10. 2. A composition as claimed in Claim 1 , wherein the polymeric micelles comprise block copolymers of poly(caprolactone ) and poly(ethyiene glycol ). 3. A composition as claimed in Claim 2, wherein the block copolymers have the general formula Rp( I -poly(i-.-caprolactone)p-L-poly( ethylene glycol Χ,-RPK, wherein RPCL is the terminal group of the pol y( r.-caprol actone ) block; p is an integer of from 4 to 1 00; L is a linker, for example selected from the group consisting of ester, amide, carbonate or carbamate; q is an integer of from 10 to 250; and RPEG is the terminal group of the poly(ethylene glycol ) block. 4. A phthalocyanine of the formula la: <img class="EMIRef" id="509797054-imgf000047-0001" /> wherein (a) M represents a metal or metal loid atom, (b) Ri, R<2>, R3, R i, R5, R., R? and Rs are independently selected from the group consisting of hydrogen, halogen, -R9, -OR9, -SR9, or -NRgRio, in which R> and Rio independently represent hydrogen, C u .alkyl, or a phenyl group optionally substituted by one or more Rn groups independently selected from the group consisting of Ci palkyl, halogen, OR 12, -SR12, and -NR12R13, in which R12 and R13 each independently represent hydrogen or Ci ^alkyl, or one or more pai s of R i and R2, R3 and R i, R5 and Re, and R? and Rx are attached to adjacent carbon atoms and together form, together with the ring to which they are attached, an aromatic fused ring system, and (c) Ra represents hydrogen or a group <img class="EMIRef" id="509797054-imgf000047-0002" /> wherein A and B independently represent a single bond, -CH2- or (C=0)-, and Ria, R?a, R3a, Rib, R?b and R<3>b independently represent hydrogen, C i-u-alkyl. -C≡CH, -COOH, -NH<2>, -CH2NH2, -SC≡N, -CH<2>SC≡N or -[OCH<2>CH<2>]n-OR, in which R represents hydrogen or G ealkyl and n represents an integer of from 1 to 1 0. 5. A phthaiocyanine of the formula lb: <img class="EMIRef" id="509797054-imgf000048-0001" /> wherein (a) M represents a metal or metalloid atom, (b) at least one of Ri, R<2>, R3, R4, R5, Re, R? and Rx is independently selected from the group consisting of -R9, -OR9, -SR9, or -NR9R10, in which R9 and Rio independently represent a phenyl group optionally substituted by one or more Rn groups independently selected from the group consisting of C<1-12>alkyl, halogen, OR i .\ -SR<12>, and -NRi<2>Ri<3>, in which Ri<2>and R13 each independently represent hydrogen or G ^alkyl, and the others of Ri, R<2>, R<3>, R t, R5, Rf>, R7 and Rx represent hydrogen or one or more pairs of the others of R i and R<2>, R<3>and R t, R5 and Re, and R? and Rx arc attached to adjacent carbon atoms and together form, together with the ring to which they are attached, an aromatic fused ring system, and (c) Ra represents hydrogen or a group <img class="EMIRef" id="509797054-imgf000048-0002" /> and Rb represents hydrogen or a group <img class="EMIRef" id="509797054-imgf000049-0001" /> wherein A and B independently represent a single bond, -CH<2>- or -(C=0)-, and Ria, R2a, R½, Rib, R211 and Rsb independently represent hydrogen, G-iealkyl, -C≡CH, -COOH, -NH2, -CH2NH2, -SC≡N, -CH<2>SC≡N or -[OCH<2>CH<2>]n-OR, in which R represents hydrogen or Chalky! and n represents an integer of from 1 to 10. 6. A composition or a phthalocyamne as claimed in any preceding claim, wherein M represents silicon. 7. A composition or a phthalocyanine as claimed in any preceding claim, wherein R<a>represents <img class="EMIRef" id="509797054-imgf000049-0002" /> and Rb represents <img class="EMIRef" id="509797054-imgf000049-0003" /> 8. A composition or a phthalocyanine as claimed in Claim 7, w herein A and B both represent -(C=0)-. 9. A composition or a phthalocyanine as claimed in Claim 7 or Claim 8, wherein one, two or all of Rib, R2b and R¾ independently represent -[OCH<2>CH<2>]<n>-OR, in which R represents hydrogen or Ci_6alkyl, preferabl y methyl, and n represents an integer of from 1 to 1 0, more preferably from 1 to 4, and in particular 3, and wherein one, two or al l of R<la>, R-2a and R<3a>independently represent -[OCH<2>CH<2>]<n>-OR, in which R represents hydrogen or C halky I, preferabl y methyl, and n represents an integer of from 1 to 1 0, more preferably from 1 to 4, and in particular 3, and/or one, two or al l of R<la>, R2a and R<3a>independently represent C i leaikyl . 1 0. A composition or a phthalocyanine as cl aimed in any preceding claim, wherein Ri, R2, R3, R i, R5, Re, R? and R« each represent hydrogen . 1 1 . A composit ion or a phthalocyanine as claimed in any one of Claims 1 to 9, wherein one or more of Ri, R<3>, R5 and R? represent hydroxyphenyi. 12. A composition as claimed in any one of Claims 1 to 3, wherein R<a>and Ri, both represent hydrogen. 1 3. A composit ion as claimed in any one of Claims 1 to 3 wherein the phthalocyanine molecules following exposure to electromagnetic radiation, produce one or more of fluorescence, phosphorescence, reactive oxygen species, heat, an optical signal and an acoustic signal. 1 4. A composition as claimed in any one of Claims 1 to 3 or Claim 1 3, in a form suitable for injection, such as a solution or dispersion in an aqueous medium, or a iyoph i ! ised material , or a form suitable for topical adm in istration, such as a gel , cream or ointment, or a form suitable for oral administration, such as a tablet or capsule, or a form suitable for direct administration to a lesion of a tissue. 1 5. A composit ion as claimed in any one of Claims 1 to 3 or Claim 1 3 or Claim 14, for use in therapy and/or diagnosis and/or therapy mon itoring and/or theranostics of a lesion of a tissue.
