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ATTENUATED LIVE STRAIN OF SALMONELLA ENTERICA SEROVAR CHOLERAESUIS AS A VACCINE AND VACCINAL VEHICLE FOR SWINE LIVESTOCKCM Patents

Attenuated live strain of Salmonella Enterica Serovar Choleraesuis as a vaccine and vaccinal vehicle for swine livestock. The present invention provides a novel live and attenuated vaccinal strain, incapable of producing the alternative sigma factor (RpoS) and which, functions as a vaccinal vehicle for heterologous antigens. The strain is constructed by means of phase deletion of the totality of the gene which codifies the alternative sigma factor, rpoS, by means of homologous recombination. The strain is avirulent, genetically stable, lacks antibiotic resistance markers and is easily differentiated from wild strains.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
WO.2009013379.A1
Fecha publicacion
29/01/2009
Anio publicacion
2009
Numero solicitud
WO2008ES00518
Fecha presentacion
24/07/2008

Etiquetas

Inventores
Dominguez Bernal GustavoDominguez Bernal, GustavoBartolome Avarza AlmiraBartolome Avarza, AlmiraTierrez-Martinez, AlbertoTierrez-Martinez AlbertoMartinez Pulgarin, SusanaMartinez Pulgarin SusanaOrden Gutierrez Jose AntonioOrden Gutierrez, Jose AntonioDe la Fuente Lopez, RicardoDe la Fuente Lopez Ricardo
Solicitantes
Universidad Complutense de Madrid
Clasificacion ipc
A61K 39/ 112 A IC12N 1/ 21 A IC12N 15/ 74 A I
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