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NOVEL ANTIVIRAL COMPOUNDSCM Patents

The present invention relates to new tricyclic organic compounds of formula (I):having antiviral activity, stereoisomers and pharmaceutically acceptable salts thereof, their use as a medicament, especially an antiviral medicament, and a pharmaceutical composition comprising the same.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.4818175.A1
Fecha publicacion
07/10/2026
Anio publicacion
2026
Numero solicitud
25382332

En detalle

Reivindicaciones

1. Compound having the formula (I): <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0103" /> wherein L is a linker, which is selected from -CH<2>- and -(C=O)-; R<1> is selected from hydrogen, linear or branched C<1>-C<6> alkyl, naphthyl, or <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0104" /> wherein n is an integer selected from 0, 1 or 2, if n is 2, the R<2> groups may be the same or different one from another, R<2> is selected from halogen, C<1>-C<3> haloalkyl, C<2>-C<10> heteroaryl, benzodioxol or <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0105" /> wherein A is a bond or is selected from -CH<2>-, -(C=O) -, O or S, m is an integer selected from 0, 1 or 2, if m is 2, the R<3> groups may be the same or different one from another, R<3> is selected from halogen, -CN, -NH<2>, -CHO, -COOH, -SO<2>CH<3>, -SO<2>NH<2>, -CONHR<4> or -OR<5>, wherein R<4> is hydrogen, C<1>-C<6> alkyl or C<5>-C<6> cycloalkyl, R<5> is hydrogen, C<1>-C<6> alkyl, C<1>-C<3> haloalkyl, and stereoisomers thereof and pharmaceutically acceptable salts thereof. 2. Compound according to claim 1, wherein linker L is -CH<2>-. 3. Compound according to any one of claims 1 or 2, wherein R<1> is selected from hydrogen, methyl, naphthyl, or <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0106" /> 4. Compound according to any one of claims 1 to 3, wherein R' is <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0107" /> and R<2> is selected from fluorine, iodine, chlorine, trifluoromethyl, pyridine, pyrimidine, pyrazole, furane, indole, benzodioxol, or <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0108" /> 5. Compound according to any one of claims 1 to 4, wherein m and n are independently 1 or 2, preferably n and m are both 1. 6. Compound according to any one of claims 1 to 5, wherein R<2> is <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0109" /> 7. Compound according to any one of claims 1 to 6, wherein R<1> is <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0110" /> R<2> is <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0111" /> and R<3> is selected from chlorine, fluorine, -CN, -NH<2>, -CHO, -COOH, -SO<2>CH<3>, -SO<2>NH<2>, -CONH<2> -CONHCH<3>, -CONH(cyclopentyl), -OH or -OCH<3>. 8. Compound according to any one of claims 1 to 7, wherein the compound is of formula (II) or (III): <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0112" /> wherein R<2> and R<3> are as defined above. 9. Compound of formula (I) according to any one of claims 1 to 8, wherein the compound is selected from: Compound N° Structure Compound N° Structure 1 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0113" /> 2 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0114" /> 3 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0115" /> 4 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0116" /> 5 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0117" /> 6 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0118" /> 7 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0119" /> 8 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0120" /> 9 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0121" /> 10 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0122" /> 11 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0123" /> 12 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0124" /> 13 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0125" /> 14 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0126" /> 15 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0127" /> 16 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0128" /> 17 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0129" /> 18 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0130" /> 19 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0131" /> 20 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0132" /> 21 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0133" /> 22 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0134" /> 23 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0135" /> 24 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0136" /> 25 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0137" /> 26 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0138" /> 27 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0139" /> 28 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0140" /> 29 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0141" /> 30 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0142" /> 31 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0143" /> 32 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0144" /> 33 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0145" /> 34 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0146" /> 35 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0147" /> 36 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0148" /> 37 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0149" /> 38 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0150" /> 39 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0151" /> 40 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0152" /> 41 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0153" /> 42 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0154" /> 43 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0155" /> 44 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0156" /> 45 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0157" /> 46 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0158" /> 47 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0159" /> 48 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0160" /> 49 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0161" /> 50 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0162" /> 51 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0163" /> 52 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0164" /> 53 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0165" /> 54 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0166" /> 55 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0167" /> 56 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0168" /> 57 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0169" /> 58 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0170" /> 59 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0171" /> 60 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0172" /> 61 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0173" /> 62 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0174" /> 63 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0175" /> 64 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0176" /> 65 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0177" /> 66 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0178" /> 67 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0179" /> 68 <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0180" /> 10. A compound of formula (I) as defined in any one of claims 1 to 9, which is: <img class="EMIRef" id="2247a607-189d-4700-a0d7-40fd64369ecb-ib0181" /> 11. A compound of formula (I) as defined in any one of claims 1 to 10, for use as a medicament. 12. A compound of formula (I) as defined in any one of claims 1 to 10, for use as a medicament for the treatment or prophylaxis of a viral infection. 13. A compound for use according to claim 12, wherein the viral infection is caused by Herpes Simplex Virus. 14. A pharmaceutical composition comprising a compound of formula (I) as defined in any one of claims 1 to 10, and at least one pharmaceutically acceptable excipient. 15. A pharmaceutical composition according to claim 14, further comprising at least one further pharmaceutically active compound, particularly a compound for the prophylaxis or treatment of a viral infection, more particularly a viral infection caused by Herpes Simplex Virus, even further particularly acyclovir.

Etiquetas

Inventores
MENÉNDEZ ARIAS, LuisANDREU SATUÉ, SabinaLÓPEZ GUERRERO, José AntonioZHAN, PengLIU, XinyongTANG, Kai
Solicitantes
Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de Madrid
Clasificacion ipc
A61K 31/ 5383 A IA61P 31/ 12 A IC07D 498/ 14 A I
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