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ANTI-CCR7 RECEPTOR ANTIBODIES FOR THE TREATMENT OF CANCERCM Patents

FIELD: medicine. ^ SUBSTANCE: invention refers to biotechnology. The pharmaceutical composition for destruction of tumor cells expressing the receptor CCR7 is described, which contains an antibody binding to the receptor CCR7, and a pharmaceutically acceptable carrier. Versions of methods of eradication of tumor cells expressing the receptor CCR7 are proposed, which include either contacting of the specified cells with an antibody that binds with the specified receptor CCR7, or administering to the patient a therapeutically effective amount of an antibody that binds with the specified receptor CCR7. ^ EFFECT: invention expands the amount of means for cancer treatment. ^ 6 cl, 8 dwg, 1 ex

Datos clave

CategoríaInvención

Índice de la ficha

Updated at
05/11/2026
Numero publicacion
EP.1904102.A1
Fecha publicacion
02/04/2008
Anio publicacion
2008

En detalle

Reivindicaciones

1. Use of an antibody which binds to a CCR7 receptor and is effective for killing tumour cells expressing said CCR7 receptor in the manufacture of a pharmaceutical composition for killing tumour cells expressing a CCR7 receptor. 2. Use according to claim 1, wherein said tumour cells are chronic lymphocytic leukaemia (CLL) cells or Mantle Cell Lymphoma (MCL) cells. 3. Use according to claim 1 or 2, wherein the antibody which binds to a CCR7 receptor is used in combination with an additional therapeutically active compound, wherein said additional therapeutically active compound is selected from the group consisting of a cytokine, an analgesic agent, an immunosuppressive agent and a chemotherapeutic agent. 4. An in vitro method for killing tumour cells expressing a CCR7 receptor which comprises contacting said cells with an antibody which binds to said CCR7 receptor and is effective for killing tumour cells expressing said CCR7 receptor. 5. Method according to claim 4, wherein said tumour cells are chronic lymphocytic leukaemia (CLL) cells or Mantle Cell Lymphoma (MCL) cells. 6. A method for identifying a compound for killing tumour cells expressing a CCR7 receptor which comprises a) contacting a cell expressing a CCR7 receptor with a candidate compound coupled to an anti-CCR7 antibody and b) determining whether said candidate compound kills said cells expressing a CCR7 receptor, wherein a compound that kills said cells expressing a CCR7 receptor, is a compound potentially useful for killing tumour cells. 7. Method according to claim 6, wherein said cells are chronic lymphocytic leukaemia (CLL) cells or Mantle Cell Lymphoma (MCL) cells. 44 8. Use of an antibody which binds to a CCR7 receptor and is effective for killing tumour cells expressing said CCR7 receptor for killing tumour cells expressing said CCR7 receptor. 9. Use according to claim 8, wherein said cells are chronic lymphocytic leukaemia (CLL) cells or Mantle Cell Lymphoma (MCL) cells.

Etiquetas

Inventores
Munoz Calleja, CeciliaMunoz Calleja CeciliaAlfonso Perez Manuel JesusAlfonso Perez, Manuel JesusLapez Giral SoniaLapez Giral, SoniaPerez Manuel Jesus AlfonsoManuel Jesus Alfonso PerezGiral Sonia LopezSonia Lopez GiralCecilia Munoz CallejaCalleja Cecilia MunozLopez Giral, SoniaLopez Giral SoniaJesus Alfonso Perez ManuelMun Os Kall Ekha SesilijaМУНЬОС КАЛЛЬЕХА Сесилия(ES)Al Fonso Peres Manuehl KhesusАЛЬФОНСО ПЕРЕС Мануэль Хесус(ES)ЛОПЕС ХИРАЛЬ Сониа(ES)Lopes Khiral SoniaAlfonso Perez, ManuelAlfonso Perez Manuel
Solicitantes
Universidad Autónoma de MadridУниверсидад Аутонома Де Мадрид
Clasificacion ipc
A61K 39/ 395 A IA61P 35/ 00 A IA61K 45/ 00 A IA61P 35/ 02 A IA61P 43/ 00 A IG01N 33/ 15 A IG01N 33/ 50 A IC07K 16/ 28 A IC07K 16/ 30 A IC12N 5/ 06 A IG01N 33/ 574 A I
Clasificacion cpc
A61K39/395&DA61K39/395&EA61K39/395&TA61P35/00A61P35/02A61P43/00&105424/130.1424/138.1424/174.1435/375435/7.23530/387.7
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