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ANTITUMOUR 1,5-DIAZAANTHRAQUINONESCM Patents

Índice de la ficha

Updated at
24/07/2026
Numero publicacion
EP.1080090.A1
Fecha publicacion
07/03/2001
Numero solicitud
EP19990923749

En detalle

Resumen

Compounds having formula (I) wherein R<3>, R<4>, R<7>, and R<8> are independently selected from the group consisting of hydrogen, lower alkyl, halogen, amine, mono(lower)alkylamine, di(lower)alkylamine, phenyl, or substituted phenyl possess antitumour activity and are new with the exception of the compound in which R<3>, R<4>, R<7>, R<8> are all hydrogen and the compound in which R<3> and R<7> are hydrogen, R<4> is chlorine, and R<8> is a 2-nitrophenyl group.

Reivindicaciones

1. A compound having the formula (I): <img class="EMIRef" id="452401486-ib0012" /> and the dihydro derivative of formula (12): <img class="EMIRef" id="452401486-ib0013" /> wherein R<3> , R<4> , R<7> and R<8> are independently selected from the group consisting of hydrogen, C<1-6> alkyl, halogen, amine, mono(C<1-6> )alkylamine, di(C<1-6> )alkylamine, or phenyl (which may be substituted with 1 to 4 substituents selected from C<1-6> alkyl, halogen, amine, mono (C<1-6> )alkylamine, di(C<1-6> )alkylamine, nitro, hydroxy, C<1-6> alkoxy, or trifluoromethyl); with the exception of the compounds in which: R<3> , R<4> , R<7> and R<8> are all hydrogen; R<3> and R<7> are hydrogen, R<4> is chlorine, and R<8> is a 2-nitrophenyl group; R<3> and R<7> are hydrogen, R<4> is amino, and R<8> is a 2-nitrophenyl group; R<3> , R<7> and R<8> are hydrogen and R<4> is chlorine; and R<4> , R<7> and R<8> are hydrogen and R<3> is methyl. 2. A compound according to claim 1, which is selected from a compound of formula (4): <img class="EMIRef" id="452401486-ib0014" /> formula (8), <img class="EMIRef" id="452401486-ib0015" /> formula (11), <img class="EMIRef" id="452401486-ib0016" /> formula (13), and <img class="EMIRef" id="452401486-ib0017" /> formula (14), <img class="EMIRef" id="452401486-ib0018" /> wherein R<3> , R<4> , R<7> and R<8> are as defined in claim 1. 3. A compound according to claim 1 or 2, wherein the substituent groups R<3> , R<4> , R<7> and R<8> are chosen from hydrogen, methyl, ethyl, chlorine, dimethylamine, and nitrophenyl. 4. A compound according to claim 1 which is selected from: 3,7-diethyl-1,5-diazaanthraquinone; 3,7-dimethyl-1,5-diazaanthraquinone; 4,8-dimethyl-1,5-diazaanthraquinone; 4,8-dimethyl-3,7-dimethyl-1,5-diazaanthraquinone; 8-chloro-3-methyl-1,5-diazaanthraquinone; 8-chloro-1-dimethylamino-4-methyl-1,4-dihydro-1,5-diazaanthraquinone; 4-chloro-8-methyl-1,5-diazaanthraquinone; and 4-dimethylamino-8-methyl-1,5-diazaanthraquinone. 5. A pharmaceutical composition which includes as active ingredient a compound of any one of claims 1 to 4, together with a pharmaceutical carrier. 6. A compound according to any one of claims 1 to 4 for use as a medicament. 7. The use of a compound according to any of claims 1 to 4 or a pharmaceutical composition according to claim 5 in the manufacture of a medicament for the treatment of tumours.

Etiquetas

Inventores
Perez Jose MariaBlanco M del MarMenendez Jose CarlosGarcia-Gravalos DoloresFuente Jesus Angel de laMartin Jesus MAvendano CarmenBlanco Maria del MarMartin Maria JesusJose Maria PerezM. del Mar BlancoJose Carlos MenendezDolores Garcia-GravalosJesus Angel de la FuenteJesus Mð MartinCarmen AvendanoMaria del Mar BlancoMaria Jesus MartinDe la Fuente Jesus AngelGarcia Gravalos DoloresDel Mar Blanco MMenendez Jose CDe la Fuente Jesus Angel InstiDe la Fuente, Jesus AngelDel Mar Blanco MariaGravalos Dolores GarciaDela Fuente Jesus AngelMartin Jesus Ma
Solicitantes
Universidad Complutense de MadridRuffles Graham KeithUniv Complutense de Madrid MadUniversidad Complutense de Madrid, MadridAvendano CarmenPerez Jose MariaBlanco Maria del MarMenendez Jose CarlosGravalos Dolores GarciaDe la Fuente Jesus AngelMartin Maria JesusDel Mar Blanco MGarcia Gravalos DoloresMartin Jesus Ma
Clasificacion ipc
A61K 31/ 4375 A IA61P 35/ 00 A IC07D 471/ 04 A I
Clasificacion cpc
4C065/AA044C065/BB094C065/CC094C065/DD024C065/EE024C065/HH024C065/JJ024C065/KK014C065/LL044C065/PP014C086/AA014C086/AA024C086/CB094C086/MA014C086/MA044C086/NA144C086/ZB26A61K31/4375A61P35/00C07D471/04C07D471/04&112Z514/290514/291514/292546/79546/81
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