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SYSTEMS, DEVICES AND METHODS FOR NON-INVASIVE HEMATOLOGICAL MEASUREMENTSCM Patents

Índice de la ficha

Updated at
24/07/2026
Numero publicacion
US.2022254024.A1
Fecha publicacion
11/08/2022
Numero solicitud
US202217666461

En detalle

Resumen

To solve the problem in which tests to derive the WBC count are invasive and there can be a certain bias of some parameters caused by inherent differences between measurements and true physiological properties.SOLUTION: A system for non-invasive hematological measurement includes a platform to receive a body portion of a user, and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of a finger so as to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), where at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries, so that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.SELECTED DRAWING: Figure 23

Reivindicaciones

1. A system, comprising: a platform to receive a body portion of a user during use; an imaging device coupled to the platform and to acquire a set of images of at least a capillary bed of the body portion; a controller, communicably coupled to the imaging device, to: detect, in each image of the set of images, one or more capillaries in the capillary bed of the body portion to identify a first set of capillaries across the set of images, by estimating one or more attributes of each capillary of the first set of capillaries, the one or more attributes including one or more structural attributes, one or more flow attributes, one or more imaging attributes, or combinations thereof, such that a first attribute of the one or more attributes of each capillary of the first set of capillaries meets a predetermined criterion for the first attribute; and identify a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images. 2. The system of claim 1, wherein the imaging device acquires the set of images as a set of frames of a video. 3. The system of claim 1, further comprising an illumination source coupled to the platform and to illuminate the body portion, wherein the imaging device acquires the set of images in response to the illumination of the body portion. 4. The system of claim 1, the one or more structural attributes selected from the group consisting of average capillary diameter, lateral capillary diameter, vertical capillary diameter capillary length, and capillary shape. 5. The system of claim 1, the one or more imaging attributes selected from the group consisting of contrast, focus, signa-to-noise ratio, and image stability. 81 6. The system of claim 1, wherein the first attribute is average capillary diameter, wherein each capillary of the second set of capillaries has an estimated average capillary diameter from about 10 µm to about 20 µm. 7. The system of claim 1, wherein the controller further: detects, for the set of images and in the second set of capillaries, a set of cellular events, each cellular event of the set of cellular events associated with passage of a white blood cell in a capillary of the second set of capillaries; and estimates an event count for the second set of capillaries based on the set of cellular events. 8. The system of claim 7, wherein the controller further: for each capillary of the second set of capillaries, estimates a quality factor; estimates the event count based on the set of cellular events and the quality factor associated with each capillary of the second set of capillaries. 9. The system of claim 8, wherein the controller further: receives a set of training images associated with capillary beds in body portions of a set of training users; generates, via supervised learning, an event count threshold based on the set of training images; classifies the user to a first user type of a set of user types based on the event count and the event count threshold, at least one user type of the set of user types associated with a diagnosis of neutropenia; and transmits an indication of the first user type to the user. 10. The system of claim 1, wherein the controller further generates a confidence value associated with the image of each capillary of the first set of capillaries in the set of images, the first set of capillaries including those capillaries for which the confidence value, for each image in which that capillary is detected, exceeds a confidence threshold. 11. The system of claim 1, wherein the controller detects the first set of capillaries by: receiving a set of training images including a specification of one or more capillaries visible within each image of the set of training images; 82 training a neural network on the set of training images; and applying the set of images to the neutral network to detect the first set of capillaries. 12. The system of claim 1, wherein the controller detects the first set of capillaries by applying the set of images to a neutral network, the neural network being trained on a set of training images including a specification of one or more capillaries visible within each image of the set of training images. 13. A method, comprising: acquiring a set of images of a capillary bed of a body portion of a user; detecting, in each image of the set of images, one or more capillaries in the body portion to identify a first set of capillaries across the set of images, the detecting including estimating one or more attributes of each capillary of the first set of capillaries, the one or more attributes including one or more structural attributes, one or more flow attributes, one or more imaging attributes, or combinations thereof, such that a first attribute of the one or more attributes of each capillary of the first set of capillaries meets a predetermined criterion for the first attribute; and identifying a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images. 14. The method of claim 13, the acquiring including acquiring the set of images as a set of frames of a video. 15. The method of claim 13, further comprising illuminating the body portion, the acquiring the set of images being in response to the illumination of the body portion. 16. The method of claim 13, the one or more structural attributes selected from the group consisting of average capillary diameter, lateral capillary diameter, vertical capillary diameter capillary length, and capillary shape. 17. The method of claim 13, the one or more imaging attributes selected from the group consisting of contrast, focus, signa-to-noise ratio, and image stability. 83 18. The method of claim 13, wherein the first attribute is average capillary diameter, wherein each capillary of the second set of capillaries has an estimated average capillary diameter from about 10 p.m to about 20 pm. 19. The method of claim 13, further comprising: detecting, for the set of images and in the second set of capillaries, a set of cellular events, each cellular event of the set of cellular events associated with passage of a white blood cell in a capillary of the second set of capillaries; and estimating an event count for the second set of capillaries based on the set of cellular events. 20. The method of claim 19, further comprising: for each capillary of the second set of capillaries, estimating a quality factor; estimating the event count based on the set of cellular events and the quality factor associated with each capillary of the second set of capillaries. 21. The method of claim 20, further comprising: receiving a set of training images associated with capillary beds in body portions of a set of training users; generating, via supervised learning, an event count threshold based on the set of training images; and classifying the user to a first user type of a set of user types based on the event count and the event count threshold, at least one user type of the set of user types associated with a diagnosis of neutropenia; and transmiting an indication of the first user type to the user. 22. The method of claim 13, further comprising generating a confidence value associated with the image of each capillary of the first set of capillaries in the set of images, the first set of capillaries including those capillaries for which the confidence value, for each image in which that capillary is detected, exceeds a confidence threshold. 23. The method of claim 13, the detecting the first set of capillaries further including: receiving a set of training images including a specification of one or more capillaries visible within each image of the set of training images; 84 training a neural network on the set of training images; and applying the set of images to the neutral network to detect the first set of capillaries. 24. The method of claim 13, the detecting the first set of capillaries further including applying the set of images to a neutral network, the neural network being trained on a set of training images including a specification of one or more capillaries visible within each image of the set of training images. 25. The method of claim 13, wherein the body portion is a nailfold portion of a finger of the user. 25. A device comprising a controller to: receive a set of images of a capillary bed in a body portion of a user; detect, in each image of the set of images, one or more capillaries in the body portion to identify a first set of capillaries across the set of images, the detecting including estimating one or more attributes of each capillary of the first set of capillaries, the one or more attributes including one or more structural attributes, one or more flow attributes, one or more imaging attributes, or combinations thereof, such that a first attribute of the one or more attributes of each capillary of the first set of capillaries meets a predetermined criterion for the first attribute; identify a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images; detect, for the set of images and in the second set of capillaries, a set of cellular events, each cellular event of the set of cellular events associated with passage of a white blood cell in a capillary of the second set of capillaries; and estimate an event count for the second set of capillaries based on the set of cellular events. 26. The device of claim 25, wherein the controller further: for each capillary of the second set of capillaries, estimates a quality factor; estimates the event count based on the set of cellular events and the quality factor associated with each capillary of the second set of capillaries. 27. The device of claim 26, wherein the controller further: receives a set of training images associated with capillary beds in body portions of a set of training users; generates, via supervised learning, an event count threshold based on the set of training images; and classifies the user to a first user type of a set of user types based on the event count and the event count threshold, at least one user type of the set of user types associated with a diagnosis of neutropenia; and transmits an indication of the first user type to the user. 28. The device of claim 25, wherein the controller further generates a confidence value associated with the image of each capillary of the first set of capillaries in the set of images, the first set of capillaries including those capillaries for which the confidence value, for each image in which that capillary is detected, exceeds a confidence threshold. 29. The device of claim 25, wherein the controller detects the first set of capillaries by: receiving a set of training images including a specification of one or more capillaries visible within each image of the set of training images; training a neural network on the set of training images; and applying the set of images to the neutral network to detect the first set of capillaries. 30. The device of claim 25, wherein the controller detects the first set of capillaries by applying the set of images to a neutral network, the neural network being trained on a set of training images including a specification of one or more capillaries visible within each image of the set of training images. 86

Etiquetas

Inventores
Castro-Gonzales CarlosButterworth IanBourquard AurelienSanchez-Ferro AlvaroTucker-Schwartz JasonPablo-Trinidad AlbertoLedmesma-Carbayo Maria JVettenburg TomCarlos Castro-GonzalesIan ButterworthAurelien BourquardAlvaro Sanchez-FerroJason Tucker-SchwartzAlberto Pablo-TrinidadMaria J Ledmesma-CarbayoTom Vettenburgカストロ-ゴンザレス カルロスバターワース イアンブカード オーレリエンサンチェス-フェッロ アルヴァロタッカー-シュワルツ ジェイソンパブロ-トリニダート アルベルトレドメスマ-カルバヨ マリア ジェイ.ヴェッテンバーグ トムCastro-Gonzalez CarlosSanchez Ferro AlvaroPablo Trinidad AlbertoLedesma Carbayo Maria JFerro Alvaro Sanchez
Solicitantes
Massachusetts Institute of TechnologyUniversidad Politécnica de Madridウニベルシダッド ポリテクニカ デ マドリード
Clasificacion ipc
A61B 5/ 02 A IA61B 5/ 145 A IG06K 9/ 46 A IG06T 7/ 136 A IA61B 5/ 1455 A IG06K 9/ 78 A IG06T 7/ 00 A IA61B 10/ 00 A IA61B 5/ 026 A IA61B 5/ 00 A IG06V 30/ 194 A IG06V 40/ 10 A IG06V 40/ 14 A I
Clasificacion cpc
4C017/AA114C017/AB034C017/AC285L096/AA025L096/BA065L096/CA045L096/EA125L096/EA335L096/FA065L096/FA265L096/FA325L096/FA525L096/FA595L096/FA645L096/FA665L096/GA515L096/HA115L096/JA115L096/KA045L096/KA15A61B10/00&EA61B5/026&120G06T7/00&350CG06T7/00&612
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