Resumen
Factor V-deficient animal model. The invention relates to a factor V-deficient non-human animal model of coagulation that includes an amino acid change in the FV protein that reproduces the human Thr1898Met mutation. Specifically, the invention relates to a mouse animal model, with the mutation located in Thr1857Met of the murine FV protein. The invention includes heterozygous and homozygous mutants for this mutation, obtaining viable litters and individuals with mild clinical signs of the disease that do not imply suffering in the animal. The invention also relates, on the one hand, to a method for obtaining non-human animals deficient in coagulation factor V through gene editing and assisted reproduction techniques by microinjection of zygotes and, on the other hand, to the use of the animal model in the study of drugs. for the treatment of coagulation factor V deficiency. (Machine-translation by Google Translate, not legally binding)