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SYNTHETIC MULTIEPITOPIC CHIMERA AS VACCINE AND TREATMENT AGAINST LEISHMANIOSIS IN MAMMALS (Machine-translation by Google Translate, not legally binding)CM Patents

Índice de la ficha

Updated at
24/07/2026
Numero publicacion
EP.4163303.A1
Fecha publicacion
12/04/2023
Numero solicitud
EP20210822305
Fecha presentacion
26/05/2021

En detalle

Resumen

Synthetic multiepitopic chimera as a vaccine and treatment against leishmaniasis in mammals. The invention relates to synthetic chimeras including 4 multiepitopic peptides against Leishmania. Each of the peptides has been selected from a Leishmania infantum protein. These are the nucleosomal histones H2A, H2B, H3 and H4. The invention also relates to a pharmaceutical composition that includes one of these synthetic chimeras. It also refers to a prophylactic and/or therapeutic vaccine against Leishmania spp for use in mammals and especially in humans and dogs. (Machine-translation by Google Translate, not legally binding)

Reivindicaciones

1. A synthetic multi-epitope chimera comprising: a.- the peptides characterised by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 and SEQ ID NO: 4, arranged in any order and separated by 0-2 amino acids, giving rise to a sequence of 70-76 amino acids; or b.- modifications of the peptides characterised by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 and SEQ ID NO: 4, arranged in any order and separated by 0-2 amino acids, giving rise to a sequence of 70-76 amino acids with, at least, 95% identity to the sequence defined in a.-. 2. The chimera according to claim 1 characterised by SEQ ID NO: 5 or with, at least, 95% identity to SEQ ID NO: 5. 3. A pharmaceutical composition comprising a synthetic multi-epitope chimera defined in any of claims 1-2, for use in mammals. 4. The pharmaceutical composition according to claim 3 comprising a pharmacologically acceptable excipient, carrier and/or adjuvant. 5. The pharmaceutical composition according to claim 4, wherein the adjuvant is saponin. 6. The pharmaceutical composition according to any of claims 3-5 for use in a prophylactic and/or therapeutic vaccine against Leishmania spp. 7. A prophylactic and/or therapeutic vaccine against Leishmania spp. comprising a synthetic multi-epitope chimera according to any of claims 1-2 or a pharmaceutical composition according to any of claims 3-6. 8. The prophylactic and/or therapeutic vaccine according to claim 7 for use against Leishmania infantum. 9. The prophylactic and/or therapeutic vaccine according to any of claims 7-8 for use in humans and/or dogs.

Etiquetas

Inventores
Martínez Rodrigo AbelMas Zubiri AliciaCarrión Herrero Francisco JavierOrden Gutiérrez José AntonioDe la Fuente López RicardoDomínguez Bernal GustavoMartinez Rodrigo AbelCarrion Herrero Francisco JavierOrden Gutierrez Jose AntonioDe la Fuente Lopez RicardoDominguez Bernal Gustavo
Solicitantes
Universidad Complutense de Madrid
Clasificacion ipc
A61K 39/ 008 A IA61P 37/ 02 A IC07K 19/ 00 A IC12N 15/ 30 A IA61K 39/ 00 A IA61P 33/ 02 A IC07K 14/ 44 A IC12N 15/ 117 A IH01M 10/ 0525 A I
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