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NEOSPORA VACCINE COMPOSITION.CM Patents

Índice de la ficha

Updated at
24/07/2026
Numero publicacion
EP.3368070.A1
Fecha publicacion
05/09/2018
Numero solicitud
EP20160795246
Fecha presentacion
28/10/2016

En detalle

Resumen

[0001] The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). [0002] La présente invention concerne de nouvelles compositions de protéines, des procédés de production desdites compositions de protéines, des compositions pharmaceutiques comprenant lesdites compositions de protéines et des procédés de traitement d'infections provoquées par Neospora caninum. En particulier, la présente invention concerne une composition de protéines comprenant les protéines spécifiées dans le tableau A en une quantité au moins environ 2 fois (facteur de changement) supérieure à celle de la même protéine lorsqu'elle est présente dans le tachyzoite entier, calculée par chromatographie liquide quantitative sans marqueur-spectrométrie de masse en tandem (CL-SM/SM).

Reivindicaciones

1. A composition comprising the following proteins in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite extract, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS), wherein the term "about" means the indicated value ± 30% of its value, preferably wherein the term "about" means the indicated value ± 20% of its value: Accession number<1> SEQ ID NO: Description<2> NCLIV_018120 177 conserved hypothetical protein NCLIV_003410 886 putative HECT-domain (ubiquitin-transferase) containing protein NCLIV_058550 347 conserved hypothetical protein NCLIV_042610 897 conserved hypothetical protein NCLIV_032910 382 hypothetical protein NCLIV_024830 519 conserved hypothetical protein NCLIV_015180 323 ATP synthase, related NCLIV_066970 453 putative enoyl-acyl carrier reductase NCLIV_025730 560 conserved hypothetical protein NCLIV_006640 289 hypothetical protein NCLIV_003470 887 putative thrombospondin type 1 domain-containing protein NCLIV_019000 390 putative adenosine transporter NCLIV_054510 785 putative heat shock protein 90 NCLIV_066350 577 Os06g0732000 protein, related NCLIV_057020 902 conserved hypothetical protein NCLIV_056680 246 hypothetical protein NCLIV_044290 463 pyruvate dehydrogenase E2 component, related NCLIV_032030 680 conserved hypothetical protein NCLIV_052240 362 putative saccharopine dehydrogenase NCLIV_008730 318 hypothetical protein NCLIV_061830 120 60S acidic ribosomal protein P0 NCLIV_002770 440 putative MORN repeat-containing protein NCLIV_014760 636 conserved hypothetical protein NCLIV_054520 322 hypothetical protein NCLIV_033810 716 hypothetical protein NCLIV_043330 121 hypothetical protein NCLIV_000430 486 conserved hypothetical protein NCLIV_030860 176 conserved hypothetical protein NCLIV_048570 58 conserved hypothetical protein NCLIV_004190 76 putative thioredoxin NCLIV_019450 459 hypothetical protein NCLIV_027160 185 conserved hypothetical protein NCLIV_044600 633 conserved hypothetical protein NCLIV_000300 307 conserved hypothetical protein NCLIV_046830 540 putative ATP synthase NCLIV_004280 315 hypothetical protein NCLIV_006720 229 conserved hypothetical protein NCLIV_046800 188 putative AGC kinase NCLIV_051960 769 conserved hypothetical protein NCLIV_010600 45 putative microneme protein MIC3 NCLIV_015920 87 Histone H4, related NCLIV_012830 285 putative MORN repeat-containing protein NCLIV_0376 1022 elongation factor Tu GTP-binding domain-containing protein NCLIV_024420 140 hypothetical protein NCLIV_036130 570 CBR-RSP-4 protein, related NCLIV_036400 156 unspecified product NCLIV_006780 397 conserved hypothetical protein NCLIV_046940 899 putative PWWP domain-containing protein NCLIV_001370 491 putative DEAD/DEAH box helicase NCLIV_001300 60 putative calmodulin NCLIV_015380 80 conserved hypothetical protein NCLIV_038990 895 conserved hypothetical protein NCLIV_043110 247 putative interferon gamma-inducible protein 30 <1> Accession number for the identified protein in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015). <2> Protein description in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015). wherein the whole tachyzoite extract is prepared by direct resuspension of 10<8> frozen tachyzoites of the Nc-Spain 7 isolate of N. caninum, with deposit number CCAP 2051/1, in 100 µl of 1% Triton-X 100 (v/v). 2. The composition according to claim 1, wherein the composition comprises the following proteins in an amount defined as indicated in the column "fold change" in the below table higher than the same protein present in the whole tachyzoite extract, as calculated by quantitative label-free LC-MS/MS analysis: Accession number<1> SEQ ID NO Fold change Description<2> NCLIV_018120 177 4.15 conserved hypothetical protein NCLIV_003410 886 3.35 putative HECT-domain (ubiquitin-transferase) containing protein NCLIV_058550 347 3.33 conserved hypothetical protein NCLIV_042610 897 3.06 conserved hypothetical protein NCLIV_032910 382 2.99 hypothetical protein NCLIV_024830 519 2.7 conserved hypothetical protein NCLIV_015180 323 2.52 ATP synthase, related NCLIV_066970 453 2.48 putative enoyl-acyl carrier reductase NCLIV_025730 560 2.47 conserved hypothetical protein NCLIV_006640 289 2.42 hypothetical protein NCLIV_003470 887 2.39 putative thrombospondin type 1 domain-containing protein NCLIV_019000 390 2.37 putative adenosine transporter NCLIV_054510 785 2.36 putative heat shock protein 90 NCLIV_066350 577 2.35 Os06g0732000 protein, related NCLIV_057020 902 2.32 conserved hypothetical protein NCLIV_056680 246 2.3 hypothetical protein NCLIV_044290 463 2.29 pyruvate dehydrogenase E2 component, related NCLIV_032030 680 2.27 conserved hypothetical protein NCLIV_052240 362 2.27 putative saccharopine dehydrogenase NCLIV_008730 318 2.22 hypothetical protein NCLIV_061830 120 2.22 60S acidic ribosomal protein P0 NCLIV_002770 440 2.18 putative MORN repeat-containing protein NCLIV_014760 636 2.17 conserved hypothetical protein NCLIV_054520 322 2.17 hypothetical protein NCLIV_033810 716 2.16 hypothetical protein NCLIV_043330 121 2.16 hypothetical protein NCLIV_000430 486 2.15 conserved hypothetical protein NCLIV_030860 176 2.14 conserved hypothetical protein NCLIV_048570 58 2.14 conserved hypothetical protein NCLIV_004190 76 2.13 putative thioredoxin NCLIV_019450 459 2.13 hypothetical protein NCLIV_027160 185 2.13 conserved hypothetical protein NCLIV_044600 633 2.13 conserved hypothetical protein NCLIV_000300 307 2.12 conserved hypothetical protein NCLIV_046830 540 2.12 putative ATP synthase NCLIV_004280 315 2.11 hypothetical protein NCLIV_006720 229 2.1 conserved hypothetical protein NCLIV_046800 188 2.1 putative AGC kinase NCLIV_051960 769 2.1 conserved hypothetical protein NCLIV_010600 45 2.09 putative microneme protein MIC3 NCLIV_015920 87 2.09 Histone H4, related NCLIV_012830 285 2.08 putative MORN repeat-containing protein NCLIV_0376 1022 2.08 elongation factor Tu GTP-binding domain-containing protein NCLIV_024420 140 2.06 hypothetical protein NCLIV_036130 570 2.06 CBR-RSP-4 protein, related NCLIV_036400 156 2.06 unspecified product NCLIV_006780 397 2.04 conserved hypothetical protein NCLIV_046940 899 2.04 putative PWWP domain-containing protein NCLIV_001370 491 2.03 putative DEAD/DEAH box helicase NCLIV_001300 60 2.02 putative calmodulin NCLIV_015380 80 2.02 conserved hypothetical protein NCLIV_038990 895 2 conserved hypothetical protein NCLIV_043110 247 2 putative interferon gamma-inducible protein 30 <1>Accesion number for the identified proteins in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015). <2> Protein description in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015). 3. The composition according to any one of claims 1 or 2, wherein the composition comprises the following proteins: Accession number1 SEQ ID NO: Description2 NCLIV_070010 1 hypothetical protein, conserved | protein length=2995 NCLIV_019110 2 HSP90-like protein, related | protein length=851 NCLIV_042820 3 cDNA FLJ58099, highly similar to Homo sapiens clathrin, heavy polypeptide-like 1 (CLTCL1), transcript variant 1, mRNA, related | protein length=1732 NCLIV_048590 4 unspecified product | protein length=1937 NCLIV_049900 5 hypothetical protein | protein length=831 NCLIV_055360 6 unspecified product | protein length=1640 NCLIV_055490 7 Heat shock protein 70 (Precursor), related | protein length=666 NCLIV_064620 8 unspecified product | protein length=1479 NCLIV_033950 9 Heat shock protein 70, related | protein length=671 NCLIV_011410 10 protein disulfide isomerase | protein length=471 NCLIV_046170 11 Heat Shock Protein 70, ER lumen, related | protein length=951 NCLIV_040880 12 hsp90, related | protein length=706 NCLIV_059600 13 putative KH domain-containing protein | protein length=950 NCLIV_014060 14 putative lysophospholipase | protein length=949 NCLIV_001670 15 elongation factor 1-alpha, related | protein length=448 NCLIV_066840 16 hypothetical protein | protein length=736 NCLIV_066020 17 hypothetical protein | protein length=316 NCLIV_001970 18 unspecified product | protein length=594 NCLIV_003050 19 putative myosin heavy chain | protein length=1123 NCLIV_ 046050 20 hypothetical protein | protein length=1226 NCLIV_020840 21 hypothetical protein | protein length=568 NCLIV_031550 22 unspecified product | protein length=425 NCLIV_019770 23 hypothetical protein | protein length=520 NCLIV_007260 24 putative p97 protein | protein length=847 NCLIV_015430 25 hypothetical protein | protein length=1915 NCLIV_067140 26 Myosin, related | protein length=1941 NCLIV_039100 27 hypothetical protein | protein length=449 NCLIV_002940 28 putative microneme protein MIC4 | protein length=595 NCLIV_045800 29 60S ribosomal protein L3, related | protein length=398 NCLIV_047860 30 hypothetical protein | protein length=763 NCLIV_031780 31 hypothetical protein | protein length=606 NCLIV_046260 32 Iron regulatory protein-like protein, related | protein length=986 NCLIV_003440 33 actin, related | protein length=376 NCLIV_015440 34 hypothetical protein | protein length=938 NCLIV_032660 35 hypothetical protein | protein length=259 NCLIV_005150 36 hypothetical protein | protein length=449 NCLIV_058890 37 tubulin alpha chain | protein length=453 NCLIV_017370 38 putative CAMP-dependent protein kinase regulatory subunit | protein length=385 NCLIV_025670 39 ATP synthase subunit beta, related | protein length=561 NCLIV_007800 40 unspecified product | protein length=1961 NCLIV_034460 41 hypothetical protein | protein length=592 NCLIV_043270 42 putative microneme protein MIC1 | protein length=460 NCLIV_033230 43 SRS domain-containing protein | protein length=319 NCLIV_065210 44 KLLA0F09449p, related | protein length=575 NCLIV_010600 45 putative microneme protein MIC3 | protein length=362 NCLIV_060730 46 unspecified product | protein length=549 NCLIV_025240 47 putative Gbp1p protein | protein length=294 NCLIV_038360 48 tsp1 domain-containing protein TSP12 (Precursor),related | protein length=1335 NCLIV_016800 49 putative TCP-1/cpn60 chaperonin family protein | protein length=576 NCLIV_068400 50 unspecified product | protein length=626 NCLIV_068460 51 unspecified product | protein length=993 NCLIV_050370 52 unspecified product | protein length=362 NCLIV_053580 53 50S ribosomal protein L4P, related | protein length=416 NCLIV_024820 54 14-3-3 protein homolog | protein length=266 NCLIV_0230 55 eukaryotic translation initiation factor 3 subunit 10 | protein length=1059 NCLIV_001520 56 eukaryotic translation initiation factor 3 subunit C, related | protein length=975 NCLIV_039400 57 hypothetical protein | protein length=704 NCLIV_048570 58 conserved hypothetical protein | protein length=251 NCLIV_025920 59 hypothetical protein | protein length=277 NCLIV_001300 60 putative calmodulin | protein length=133 NCLIV_068920 61 SRS domain-containing protein | protein length=387 NCLIV_036700 62 putative M16 family peptidase | protein length=1408 NCLIV_002520 63 hypothetical protein | protein length=263 NCLIV_045585 64 conserved hypothetical protein | protein length=513 NCLIV_061170 65 hypothetical protein | protein length=842 NCLIV_025190 66 LOC549444 protein, related | protein length=183 NCLIV_011980 67 calmodulin-like domain protein kinase isoenzyme gamma, related | protein length=506 NCLIV_034130 68 hypothetical protein | protein length=598 NCLIV_012920 69 unspecified product | protein length=391 NCLIV_032430 70 conserved hypothetical protein | protein length=474 NCLIV_021050 71 unspecified product | protein length=865 NCLIV_058440 72 Os02g0824100 protein, related | protein length=495 NCLIV_030050 73 unspecified product | protein length=890 NCLIV_008850 74 conserved hypothetical protein | protein length=1981 NCLIV_000010 75 putative heat shock protein 90 | protein length=818 NCLIV_004190 76 putative thioredoxin | protein length=428 NCLIV_020220 77 putative elongation factor 2 | protein length=832 NCLIV_061160 78 putative acid phosphatase | protein length=436 NCLIV_017500 79 hypothetical protein | protein length=192 NCLIV_015380 80 conserved hypothetical protein | protein length=338 NCLIV_050590 81 GL11864, related | protein length=503 NCLIV_024740 82 Myosin, heavy polypeptide 1, skeletal muscle,adult, related | protein length=766 NCLIV_0341 83 eukaryotic translation initiation factor 3 subunit 6 interacting protein | protein length=643 NCLIV_031670 84 conserved hypothetical protein | protein length=582 NCLIV_030940 85 hypothetical protein | protein length=1079 NCLIV_065470 86 hypothetical protein | protein length=458 NCLIV_015920 87 Histone H4, related | protein length=103 NCLIV_010730 88 srs domain-containing protein | protein length=387 NCLIV_033690 89 hypothetical protein | protein length=756 NCLIV_068850 90 unspecified product | protein length=557 NCLIV_032390 91 conserved hypothetical protein | protein length=225 NCLIV_021080 92 hypothetical protein | protein length=260 NCLIV_015880 93 hypothetical protein | protein length=196 NCLIV_048460 94 putative thioredoxin | protein length=623 NCLIV_010320 95 putative dihydrolipoamide branched chain transacylase, E2 subunit | protein length=656 NCLIV_042410 96 putative sortilin | protein length=951 NCLIV_015410 97 hypothetical protein | protein length=166 NCLIV_037190 98 putative glyceraldehyde-3-phosphate dehydrogenase | protein length=1028 NCLIV_060820 99 V-type ATP synthase beta chain, related | protein length=505 NCLIV_000390 100 conserved hypothetical protein | protein length=412 NCLIV_050470 101 hypothetical protein | protein length=530 NCLIV_012120 102 hypothetical protein | protein length=261 NCLIV_041740 103 conserved hypothetical protein | protein length=950 NCLIV_016850 104 AT3G15980 protein, related | protein length=1239 NCLIV_031970 105 hypothetical protein | protein length=2552 NCLIV_041180 106 60s ribosomal protein L10, related | protein length=221 NCLIV_030420 107 Rcn2-prov protein, related | protein length=350 NCLIV_010720 108 srs domain-containing protein | protein length=406 NCLIV_036830 109 conserved hypothetical protein | protein length=909 NCLIV_045460 110 Mitochondrial presequence protease (Precursor), related | protein length=1311 NCLIV_024880 111 30S ribosomal protein S9P, related | protein length=148 NCLIV_062720 112 hypothetical protein | protein length=205 NCLIV_025160 113 hypothetical protein | protein length=146 NCLIV_054140 114 putative adenylyl cyclase associated protein | protein length=223 NCLIV_052390 115 hypothetical protein | protein length=217 NCLIV_067010 116 Mitochondrial phosphate carrier protein, related | protein length=334 NCLIV_066310 117 DEAD-box ATP-dependent RNA helicase 34, related | protein length=411 NCLIV_015210 118 putative ATP-dependent helicase, putaive | protein length=395 NCLIV_022220 119 hypothetical protein | protein length=574 NCLIV_061830 120 60S acidic ribosomal protein P0 | protein length=311 NCLIV_043330 121 hypothetical protein | protein length=203 NCLIV_024630 122 putative porin | protein length=290 NCLIV_032290 123 SSU ribosomal protein S3P, related | protein length=235 NCLIV_056430 124 conserved hypothetical protein | protein length=438 NCLIV_018530 125 conserved hypothetical protein | protein length=955 NCLIV_065090 126 conserved hypothetical protein | protein length=695 NCLIV_049050 127 RNA helicase-related protein required for pre-mRNA splicing, related | protein length=2230 NCLIV_047660 128 hypothetical protein | protein length=477 NCLIV_052350 129 conserved hypothetical protein | protein length=244 NCLIV_064950 130 hypothetical protein | protein length=505 NCLIV_029990 131 putative vacuolar ATP synthase catalytic subunit A | protein length=573 NCLIV_050680 132 hypothetical protein | protein length=578 NCLIV_038400 133 methionine aminopeptidase,related | protein length=404 NCLIV_020250 134 hypothetical protein | protein length=556 NCLIV_067180 135 Glucose-6-phosphate 1-dehydrogenase, related | protein length=728 NCLIV_023090 136 hypothetical protein | protein length=376 NCLIV_045010 137 hypothetical protein | protein length=205 NCLIV_032270 138 conserved hypothetical protein | protein length=330 NCLIV_047810 139 hypothetical protein | protein length=257 NCLIV_024420 140 hypothetical protein | protein length=353 NCLIV_044000 141 hypothetical protein | protein length=268 NCLIV_003310 142 hypothetical protein | protein length=312 NCLIV_062520 143 3-ketoacyl-(Acyl-carrier-protein) reductase, related | protein length=376 NCLIV_010740 144 putative kelch motif domain-containing protein | protein length=398 NCLIV_069590 145 hypothetical protein | protein length=557 NCLIV_044200 146 hypothetical protein | protein length=620 NCLIV_031770 147 putative membrane skeletal protein IMC1 | protein length=436 NCLIV_024870 148 hypothetical protein | protein length=212 NCLIV_028680 149 putative apical membrane antigen 1 | protein length=569 NCLIV_067350 150 putative P-type Ca(2+)-ATPase | protein length=1341 NCLIV_055720 151 hypothetical protein | protein length=1794 NCLIV_032330 152 Malate dehydrogenase (NAD) (Precursor), related | protein length=329 NCLIV_018420 153 unspecified product | protein length=347 NCLIV_037520 154 conserved hypothetical protein | protein length=536 NCLIV_055760 155 conserved hypothetical protein | protein length=550 NCLIV_036400 156 unspecified product | protein length=190 NCLIV_007770 157 putative Rhoptry kinase family protein, truncated (incomplete catalytic triad) | protein length=378 NCLIV_057950 158 unspecified product | protein length=945 NCLIV_002590 159 phthalate dioxygenase reductase subunit, related | protein length=681 NCLIV_055850 160 unspecified product | protein length=406 NCLIV_046690 161 VASA RNA helicase, related | protein length=769 NCLIV_065270 162 hypothetical protein | protein length=544 NCLIV_020720 163 putative microneme protein MIC11 | protein length=203 NCLIV_064700 164 Ribosomal protein L18, related | protein length=187 NCLIV_011730 165 unspecified product | protein length=540 NCLIV_005620 166 putative articulin 4 | protein length=466 NCLIV_056480 167 hypothetical protein | protein length=540 NCLIV_035250 168 GK18150, related | protein length=642 NCLIV_057820 169 hypothetical protein | protein length=847 NCLIV_001070 170 histone H2B, related | protein length=116 NCLIV_066630 171 unspecified product | protein length=318 NCLIV_064360 172 50S ribosomal protein L24P, related | protein length=141 NCLIV_009450 173 60s ribosomal protein L17, related | protein length=195 NCLIV_010200 174 hypothetical protein | protein length=311 NCLIV_000510 175 putative translocation protein sec62 | protein length=390 NCLIV_030860 176 conserved hypothetical protein | protein length=564 NCLIV_018120 177 conserved hypothetical protein | protein length=686 NCLIV_039030 178 hypothetical protein | protein length=134 NCLIV_029420 179 putative myosin light chain TgMLC1 | protein length=216 NCLIV_036280 180 30S ribosomal protein S15P/S13e, related | protein length=151 NCLIV_032780 181 putative small heat shock protein 20 | protein length=228 NCLIV_065010 182 hypothetical protein | protein length=210 NCLIV_046040 183 hypothetical protein | protein length=161 NCLIV_041930 184 unspecified product | protein length=201 NCLIV_027160 185 conserved hypothetical protein | protein length=250 NCLIV_064440 186 hypothetical protein | protein length=188 NCLIV_049600 187 30S ribosomal protein S8P, related | protein length=171 NCLIV_046800 188 putative AGC kinase | protein length=343 NCLIV_066600 189 DEHA2F06798p, related | protein length=454 NCLIV_028170 190 unspecified product | protein length=581 NCLIV_055710 191 putative 60S ribosomal protein L23 | protein length=139 NCLIV_011700 192 unspecified product | protein length=316 NCLIV_037500 193 unspecified product | protein length=475 NCLIV_036610 194 hypothetical protein | protein length=473 NCLIV_038850 195 putative fumarase | protein length=609 NCLIV_065590 196 putative NAD-specific glutamate dehydrogenase | protein length=1122 NCLIV_056700 197 26S proteasome regulatory subunit rpn1, related | protein length=1084 NCLIV_014360 198 hypothetical protein | protein length=1037 NCLIV_043930 199 kelch repeat-containing proteins that is fused to a HSP90-like ATpase, related | protein length=1938 NCLIV_013150 200 conserved hypothetical protein | protein length=330 NCLIV_032110 201 conserved hypothetical protein | protein length=460 NCLIV_015160 202 hypothetical protein | protein length=190 NCLIV_024840 203 hypothetical protein | protein length=469 NCLIV_032770 204 hypothetical protein | protein length=909 NCLIV_018400 205 putative TCP-1/cpn60 family chaperonin | protein length=569 NCLIV_033250 206 SRS domain-containing protein | protein length=401 NCLIV_063860 207 putative thioredoxin | protein length=250 NCLIV_060660 208 SRS domain-containing protein | protein length=357 NCLIV_041780 209 lsu ribosomal protein L19E, related | protein length=186 NCLIV_027600 210 conserved hypothetical protein | protein length=592 NCLIV_060220 211 conserved hypothetical protein | protein length=2981 NCLIV_004160 212 histone H2B, related | protein length=123 NCLIV_062950 213 50S ribosomal protein L21e, related | protein length=157 NCLIV_031510 214 hypothetical protein | protein length=145 NCLIV_056670 215 conserved hypothetical protein | protein length=274 NCLIV_048020 216 hypothetical protein | protein length=328 NCLIV_000740 217 class I chitinase, related | protein length=708 NCLIV_051820 218 hypothetical protein | protein length=202 NCLIV_042590 219 2-oxoglutarate dehydrogenase E1 component,related | protein length=361 NCLIV_054800 220 conserved hypothetical protein | protein length=623 NCLIV_000940 221 putative Glucose-6-phosphate dehydrogenase | protein length=486 NCLIV_059430 222 hypothetical protein | protein length=321 NCLIV_018800 223 hypothetical protein | protein length=1125 NCLIV_062460 224 conserved hypothetical protein | protein length=1998 NCLIV_063970 225 putative long chain acyl-CoA synthetase | protein length=828 NCLIV_004860 226 hypothetical protein | protein length=2559 NCLIV_043760 227 conserved hypothetical protein | protein length=165 NCLIV_030820 228 conserved hypothetical protein | protein length=142 NCLIV_006720 229 conserved hypothetical protein | protein length=203 NCLIV_016540 230 conserved hypothetical protein | protein length=444 NCLIV_054120 231 unspecified product | protein length=1102 NCLIV_042450 232 putative opine dehydrogenase | protein length=435 NCLIV_031340 233 putative Splicing factor 3B subunit 3 | protein length=1233 NCLIV_015620 234 60S ribosomal protein L36, related | protein length=101 NCLIV_066250 235 unspecified product | protein length=198 NCLIV_042070 236 hypothetical protein | protein length=332 NCLIV_011270 237 hypothetical protein | protein length=418 NCLIV_022970 238 unspecified product | protein length=765 NCLIV_005010 239 conserved hypothetical protein | protein length=560 NCLIV_028750 240 hypothetical protein | protein length=1232 NCLIV 030660 241 putative TCP-1/cpn60 family chaperonin | protein length=548 NCLIV_034530 242 putative TCP-1/cpn60 family chaperonin | protein length=542 NCLIV_025580 243 eukaryotic translation initiation factor 3 subunit 11 | protein length=271 NCLIV_032050 244 putative DnaJ domain-containing protein | protein length=851 NCLIV_055730 245 hypothetical protein | protein length=764 NCLIV_056680 246 hypothetical protein | protein length=193 NCLIV_043110 247 putative interferon gamma-inducible protein 30 | protein length=386 NCLIV_053290 248 ORF73, related | protein length=1540 NCLIV_054570 249 60S ribosomal protein Ll28B 27a, related | protein length=147 NCLIV_026150 250 Histone H3, related | protein length=136 NCLIV_028540 251 conserved hypothetical protein | protein length=275 NCLIV_014020 252 Peroxiredoxin-2E-1, related | protein length=267 NCLIV_060140 253 putative inner membrane complex protein IMC3 | protein length=535 NCLIV_038320 254 unspecified product | protein length=1111 NCLIV_034270 255 putative coatomer gamma 2-subunit protein | protein length=1032 NCLIV_006070 256 30s ribosomal protein S10P, related | protein length=118 NCLIV_024250 257 hypothetical protein | protein length=158 NCLIV_047630 258 putative 40S ribosomal protein S18 | protein length=156 NCLIV_053840 259 unspecified product | protein length=355 NCLIV_022950 260 putative RNA-binding protein | protein length=277 NCLIV_027480 261 hypothetical protein | protein length=395 NCLIV_033680 262 Solute carrier family 25 (Mitochondrial carrier,dicarboxylate transporter), member 10, related | protein length=336 NCLIV_059450 263 hypothetical protein | protein length=434 NCLIV_061040 264 hypothetical protein | protein length=476 NCLIV_050210 265 putative KH domain-containing protein | protein length=616 NCLIV_005900 266 translation INITIATION FACTOR 3 SUBUNIT 9-like protein, related | protein length=759 NCLIV_065450 267 hypothetical protein | protein length=112 NCLIV_027780 268 conserved hypothetical protein | protein length=153 NCLIV_033270 269 hypothetical protein | protein length=385 NCLIV_030930 270 putative peroxiredoxin 3 | protein length=289 NCLIV_062940 271 putative pyruvate dehydrogenase | protein length=559 NCLIV_064420 272 putative ubiquitin | protein length=215 NCLIV_020180 273 hypothetical protein | protein length=490 NCLIV_064880 274 conserved hypothetical protein | protein length=1222 NCLIV_004790 275 putative 18 kDa cyclophilin | protein length=178 NCLIV_030490 276 30S ribosomal protein S12, related | protein length=143 NCLIV_052190 277 conserved hypothetical protein | protein length=435 NCLIV_004730 278 hypothetical protein | protein length=380 NCLIV_042650 279 gg11844, related | protein length=460 NCLIV_015010 280 conserved hypothetical protein | protein length=648 NCLIV_030890 281 putative high molecular mass nuclear antigen | protein length=918 NCLIV 034090 282 putative kinesin heavy chain | protein length=1823 NCLIV_030620 283 conserved hypothetical protein | protein length=228 NCLIV_070060 284 RNA binding protein, putative | protein length=387 NCLIV_012830 285 putative MORN repeat-containing protein | protein length=457 NCLIV 043300 286 putative nucleolar phosphoprotein nucleolin | protein length=710 NCLIV_025450 287 putative elongation factor Tu | protein length=488 NCLIV_060420 288 hypothetical protein | protein length=781 NCLIV_006640 289 hypothetical protein | protein length=3982 NCLIV_059340 290 conserved hypothetical protein | protein length=624 NCLIV_009640 291 putative choline kinase | protein length=558 NCLIV_054720 292 hypothetical protein | protein length=925 NCLIV_040970 293 putative malate:quinone oxidoreductase | protein length=551 NCLIV_045870 294 unspecified product | protein length=207 NCLIV_062570 295 Contig An13c0020, complete genome, related | protein length=463 NCLIV_040440 296 conserved hypothetical protein | protein length=880 NCLIV_040540 297 hypothetical protein | protein length=434 NCLIV_053880 298 cDNA FLJ54097, highly similar to Succinyl-CoA ligase (ADP-forming) beta-chain, mitochondrial, related | protein length=495 NCLIV_041790 299 conserved hypothetical protein | protein length=915 NCLIV_057700 300 hypothetical protein | protein length=248 NCLIV_051340 301 putative toxofilin | protein length=291 NCLIV_038780 302 60s ribosomal protein L32, related | protein length=134 NCLIV_028090 303 conserved hypothetical protein | protein length=165 NCLIV_053950 304 hypothetical protein | protein length=175 NCLIV_024030 305 conserved hypothetical protein | protein length=221 NCLIV_026600 306 putative 46 kDa FK506-binding nuclear protein | protein length=314 NCLIV_000300 307 conserved hypothetical protein | protein length=254 NCLIV_041940 308 glyceraldehyde 3-phosphate dehydrogenase, related | protein length=340 NCLIV_026820 309 conserved hypothetical protein | protein length=158 NCLIV_004400 310 hypothetical protein | protein length=475 NCLIV_041120 311 conserved hypothetical protein | protein length=388 NCLIV_016110 312 hypothetical protein | protein length=377 NCLIV_020770 313 hypothetical protein | protein length=521 NCLIV_004710 314 hypothetical protein | protein length=685 NCLIV_004280 315 hypothetical protein | protein length=762 NCLIV_001570 316 eukaryotic translation initiation factor 3 subunit G-2, related | protein length=1870 NCLIV_001450 317 hypothetical protein | protein length=4864 NCLIV_008730 318 hypothetical protein | protein length=165 NCLIV_045650 319 unspecified product | protein length=211 NCLIV_063980 320 conserved hypothetical protein | protein length=167 NCLIV_033780 321 YALI0B05610p, related | protein length=199 NCLIV_054520 322 hypothetical protein | protein length=363 NCLIV_015180 323 ATP synthase, related | protein length=252 NCLIV_060400 324 hypothetical protein | protein length=169 NCLIV_041100 325 novel protein (Zgc:66430), related | protein length=279 NCLIV_006490 326 putative myosin light chain 2 | protein length=368 NCLIV 023620 327 SRS domain-containing protein | protein length=325 NCLIV_028050 328 conserved hypothetical protein | protein length=281 NCLIV_006180 329 putative duplicated carbonic anhydrase | protein length=522 NCLIV_070280 330 hypothetical protein | protein length=472 NCLIV 012130 331 eukaryotic translation initiation factor 3 subunit 7-like protein, related | protein length=529 NCLIV_023790 332 conserved hypothetical protein | protein length=339 NCLIV_018550 333 YGR231Cp-like protein, related | protein length=271 NCLIV_008230 334 delta-aminolevulinic acid dehydratase, related | protein length=669 NCLIV_022540 335 conserved hypothetical protein | protein length=580 NCLIV_060380 336 hypothetical protein | protein length=415 NCLIV_027530 337 putative lectin-domain protein | protein length=683 NCLIV_032920 338 hypothetical protein | protein length=560 NCLIV_068890 339 unspecified product | protein length=553 NCLIV_062280 340 conserved hypothetical protein | protein length=341 NCLIV_011210 341 transketolase, related | protein length=986 NCLIV_061990 342 conserved hypothetical protein | protein length=1344 NCLIV_001250 343 putative guanylate binding protein | protein length=1361 NCLIV_020360 344 40S ribosomal protein S12, related | protein length=142 NCLIV_018890 345 L24, related | protein length=154 NCLIV_036410 346 putative cyst matrix protein | protein length=456 NCLIV_058550 347 conserved hypothetical protein | protein length=157 NCLIV_045220 348 hypothetical protein | protein length=398 NCLIV_000130 349 hypothetical protein | protein length=494 NCLIV_060700 350 SRS domain-containing protein | protein length=351 NCLIV_044410 351 unspecified product | protein length=592 NCLIV_038750 352 putative DNAJ domain-containing protein | protein length=420 NCLIV_028060 353 conserved hypothetical protein | protein length=547 NCLIV_030900 354 hypothetical protein | protein length=1236 NCLIV_041240 355 nadh dehydrogenase, related | protein length=646 NCLIV_014150 356 unspecified product | protein length=130 NCLIV_028240 357 putative Ras family domain-containing protein | protein length=217 NCLIV_046550 358 Elongation factor 1-beta, related | protein length=242 NCLIV_062730 359 hypothetical protein | protein length=331 NCLIV_064310 360 GTP-binding nuclear protein Ran, related | protein length=216 NCLIV_043400 361 proteasome subunit p58, related | protein length=554 NCLIV_052240 362 putative saccharopine dehydrogenase | protein length=450 NCLIV_054200 363 Zgc:92083, related | protein length=846 NCLIV_021720 364 conserved hypothetical protein | protein length=729 NCLIV_018500 365 Fatty acyl-CoA synthetase 2, related | protein length=817 NCLIV_049030 366 hypothetical protein | protein length=225 NCLIV_029080 367 hypothetical protein | protein length=223 NCLIV_041830 368 os07g0543600 protein, related | protein length=460 NCLIV_006510 369 putative TCP-1/cpn60 family chaperonin | protein length=546 NCLIV_051450 370 putative centromere/microtubule binding protein | protein length=503 NCLIV_054250 371 Acyl-CoA synthetase, related | protein length=766 NCLIV_049100 372 Ribosomal protein S19e, related | protein length=160 NCLIV_057960 373 unspecified product | protein length=1044 NCLIV_002780 374 yml024wp-like protein, related | protein length=132 NCLIV_052230 375 Succinate dehydrogenase iron-sulfur subunit,related | protein length=339 NCLIV 056360 376 Eukaryotic initiation factor, related | protein length=487 NCLIV_056300 377 conserved hypothetical protein | protein length=490 NCLIV_066870 378 hypothetical protein | protein length=161 NCLIV_048030 379 hypothetical protein | protein length=120 NCLIV_006060 380 conserved hypothetical protein | protein length=239 NCLIV_015480 381 emp24/gp25L/p24 family domain-containing,transmembrane protein | protein length=255 NCLIV_032910 382 hypothetical protein | protein length=377 NCLIV_039090 383 conserved hypothetical protein | protein length=306 NCLIV_051560 384 Glucose transporter 1A, related | protein length=487 NCLIV_007450 385 unspecified product | protein length=552 NCLIV_012400 386 Articulin family protein, related | protein length=462 NCLIV_063340 387 hypothetical protein | protein length=651 NCLIV_020990 388 hypothetical protein | protein length=1067 NCLIV_051010 389 putative signal peptide peptidase domain-containing protein | protein length=467 NCLIV_019000 390 putative adenosine transporter | protein length=465 NCLIV_060760 391 putative prolyl-tRNA synthetase | protein length=656 NCLIV_000840 392 thioredoxin h, related | protein length=106 NCLIV_060860 393 Cytochrome c, related | protein length=115 NCLIV_064530 394 Histone H2A, related | protein length=155 NCLIV_027290 395 Ribosomal protein S21-maize (ISS), related | protein length=82 NCLIV_007110 396 hypothetical protein | protein length=151 NCLIV_006780 397 conserved hypothetical protein | protein length=196 NCLIV_064840 398 conserved hypothetical protein | protein length=283 NCLIV_019970 399 Peptidyl-prolyl cis-trans isomerase A, related | protein length=172 NCLIV_011550 400 novel protein (Zgc:77155), related | protein length=206 NCLIV_012195 401 unspecified product | protein length=161 NCLIV_0260 402 armadillo/beta-catenin-like repeat-containing protein | protein length=274 NCLIV_051840 403 hypothetical protein | protein length=289 NCLIV_043880 404 hypothetical protein | protein length=238 NCLIV_055690 405 hypothetical protein | protein length=214 NCLIV_054750 406 hypothetical protein | protein length=306 NCLIV_065970 407 conserved hypothetical protein | protein length=386 NCLIV_030170 408 hypothetical protein | protein length=129 NCLIV_004380 409 cathepsin L, related | protein length=415 NCLIV_035910 410 hypothetical protein | protein length=778 NCLIV_039080 411 adaptin N terminal region family protein,related | protein length=1117 NCLIV_042390 412 conserved hypothetical protein | protein length=237 NCLIV_033850 413 hypothetical protein | protein length=1613 NCLIV_064540 414 Ribosomal protein L37a, related | protein length=96 NCLIV_000860 415 spatr, related | protein length=545 NCLIV_004750 416 putative peptidase family M48 domain-containing protein | protein length=429 NCLIV_047520 417 conserved hypothetical protein | protein length=372 NCLIV_066900 418 putative serine/threonine protein phosphatase 5 | protein length=1035 NCLIV_062630 419 Thioredoxin-dependent peroxide reductase,mitochondrial, related | protein length=200 NCLIV_051490 420 conserved hypothetical protein | protein length=80 NCLIV_029730 421 putative Ras family domain-containing protein | protein length=214 NCLIV_050300 422 GH18750, related | protein length=465 NCLIV_038000 423 CUG-BP-and ETR-3-like factor 3, related | protein length=678 NCLIV_056550 424 Translation initiation factor 2 subunit alpha (AeIF-2a), related | protein length=352 NCLIV_063370 425 conserved hypothetical protein | protein length=388 NCLIV_045260 426 hypothetical protein | protein length=585 NCLIV_003190 427 putative mitochondrial carrier domain-containing protein | protein length=476 NCLIV_053330 428 conserved hypothetical protein | protein length=660 NCLIV_004300 429 putative dynamin-like protein | protein length=870 NCLIV_067050 430 conserved hypothetical protein | protein length=543 NCLIV_002390 431 nucleoside diphosphate kinase,related | protein length=155 NCLIV_020650 432 putative splicing factor 3B subunit 1 | protein length=1392 NCLIV_055160 433 conserved hypothetical protein | protein length=4555 NCLIV_018290 434 Ribosomal protein S26E, related | protein length=113 NCLIV_016380 435 Ribosomal protein L22, related | protein length=181 NCLIV_003650 436 hypothetical protein | protein length=336 NCLIV_004920 437 hypothetical protein | protein length=248 NCLIV_058840 438 conserved hypothetical protein | protein length=242 NCLIV_052500 439 hypothetical protein | protein length=299 NCLIV_002770 440 putative MORN repeat-containing protein | protein length=385 NCLIV_069630 441 hypothetical protein, conserved | protein length=239 NCLIV_034990 442 Transketolase, pyridine binding domain protein,related | protein length=483 NCLIV_066100 443 putative microtubule-binding protein | protein length=835 NCLIV_018020 444 hypothetical protein | protein length=1499 NCLIV_013260 445 conserved hypothetical protein | protein length=190 NCLIV_012510 446 hypothetical protein | protein length=118 NCLIV_013320 447 hypothetical protein | protein length=150 NCLIV_052380 448 hypothetical protein | protein length=135 NCLIV_062890 449 hypothetical protein | protein length=154 NCLIV_031040 450 Peptidyl-prolyl cis-trans isomerase,related | protein length=172 NCLIV_045670 451 hypothetical protein | protein length=134 NCLIV_034470 452 hypothetical protein | protein length=188 NCLIV_066970 453 putative enoyl-acyl carrier reductase | protein length=400 NCLIV_046530 454 putative reticulon domain-containing protein | protein length=197 NCLIV_061940 455 hypothetical protein | protein length=482 NCLIV_069550 456 unspecified product | protein length=463 NCLIV_026430 457 DnaJ domain containing protein, related | protein length=614 NCLIV_049570 458 hypothetical protein | protein length=584 NCLIV_019450 459 hypothetical protein | protein length=223 NCLIV_025010 460 hypothetical protein | protein length=337 NCLIV_016970 461 conserved hypothetical protein | protein length=579 NCLIV_031460 462 conserved hypothetical protein | protein length=510 NCLIV_044290 463 pyruvate dehydrogenase E2 component, related | protein length=920 NCLIV 042660 464 probable cytosol aminopeptidase, related | protein length=564 NCLIV_064580 465 hypothetical protein | protein length=392 NCLIV_014950 466 putative trans-2,3-enoyl-CoA reductase | protein length=298 NCLIV_005420 467 phosphoglycerate kinase, related | protein length=556 NCLIV_006570 468 putative serine/threonine protein phosphatase | protein length=692 NCLIV_054110 469 YHL017Wp-like protein, related | protein length=733 NCLIV_009390 470 putative Cleft lip and palate transmembrane protein 1 | protein length=626 NCLIV_051800 471 conserved hypothetical protein | protein length=1102 NCLIV_032220 472 50S ribosomal protein L30e, related | protein length=108 NCLIV_052510 473 hypothetical protein | protein length=111 NCLIV_016120 474 putative proteasome subunit alpha type 4, subunit | protein length=252 NCLIV_038680 475 hypothetical protein | protein length=230 NCLIV_047080 476 conserved hypothetical protein | protein length=128 NCLIV_032560 477 hypothetical protein | protein length=680 NCLIV_038540 478 rab22a, member RAS oncogene family, related | protein length=241 NCLIV_042050 479 hypothetical protein | protein length=232 NCLIV_063740 480 conserved hypothetical protein | protein length=450 NCLIV_032620 481 Cs1 protein, related | protein length=438 NCLIV_060500 482 conserved hypothetical protein | protein length=550 NCLIV_029570 483 conserved hypothetical protein | protein length=501 NCLIV_007390 484 mgc78841 protein, related | protein length=554 NCLIV_014430 485 conserved hypothetical protein | protein length=738 NCLIV_000430 486 conserved hypothetical protein | protein length=393 NCLIV_069130 487 hypothetical protein, conserved | protein length=813 NCLIV_015200 488 Pyruvate kinase, related | protein length=531 NCLIV_044350 489 conserved hypothetical protein | protein length=432 NCLIV_024860 490 Proteasome/cyclosome repeat family protein,related | protein length=1181 NCLIV_001370 491 putative DEAD/DEAH box helicase | protein length=2249 NCLIV_015790 492 putative fatty acyl-CoA desaturase | protein length=1386 NCLIV_040610 493 virulent strain associated lipoprotein, related | protein length=2597 NCLIV_000710 494 conserved hypothetical protein | protein length=221 NCLIV_045240 495 putative eukaryotic translation initiation factor 3 subunit 5 | protein length=346 NCLIV_061210 496 conserved hypothetical protein | protein length=393 NCLIV_069600 497 hypothetical protein, conserved | protein length=268 NCLIV_048880 498 Proteasome subunit beta type-7, related | protein length=242 NCLIV_048040 499 conserved hypothetical protein | protein length=492 NCLIV_029860 500 hypothetical protein | protein length=194 NCLIV_019830 501 hypothetical protein | protein length=262 NCLIV_009780 502 beta-lactamase domain protein (Precursor),related | protein length=1133 NCLIV_022140 503 GA11385, related | protein length=564 NCLIV_018710 504 hypothetical protein | protein length=454 NCLIV_016370 505 Galactosyltransferase, related | protein length=1298 NCLIV_041650 506 methionine--tRNAligase, related | protein length=982 NCLIV_050390 507 Pyrroline-5-carboxylate reductase,related | protein length=275 NCLIV_039000 508 probable 26S protease regulatory subunit 6B,related | protein length=443 NCLIV 068380 509 hypothetical protein | protein length=489 NCLIV_047390 510 conserved hypothetical protein | protein length=502 NCLIV_025000 511 hypothetical protein | protein length=1045 NCLIV_037760 512 Rhomboid-6, isoform A, related | protein length=646 NCLIV_051890 513 unspecified product | protein length=2001 NCLIV_002380 514 conserved hypothetical protein | protein length=277 NCLIV_020340 515 unspecified product | protein length=2592 NCLIV_012230 516 Ribose-phosphate pyrophosphokinase,related | protein length=555 NCLIV_068970 517 Succinate dehydrogenase flavoprotein subunit,related | protein length=420 NCLIV_012890 518 hypothetical protein | protein length=7289 NCLIV_024830 519 conserved hypothetical protein | protein length=139 NCLIV_011320 520 vesicle-associated membrane protein-associated protein A, related | protein length=239 NCLIV_062310 521 Function: human SRp75 can complement a splicing-deficient extract, related | protein length=353 NCLIV_018510 522 Hydrolase Cof, related | protein length=319 NCLIV_060800 523 Ubiquitin, related | protein length=535 NCLIV_044230 524 putative peptidase M16 domain containing protein | protein length=2231 NCLIV_010010 525 het-R, related | protein length=515 NCLIV_062770 526 unspecified product | protein length=682 NCLIV_039500 527 hypothetical protein | protein length=4520 NCLIV_004140 528 hypothetical protein | protein length=151 NCLIV_025910 529 Histone H2A, related | protein length=135 NCLIV_021640 530 unspecified product | protein length=217 NCLIV_011820 531 agap011504-PA, related | protein length=99 NCLIV_006030 532 putative dynein light chain | protein length=89 NCLIV_061560 533 conserved hypothetical protein | protein length=147 NCLIV_000610 534 putative profilin family protein | protein length=163 NCLIV_053870 535 hypothetical protein | protein length=132 NCLIV_041210 536 putative Ubiquinol-cytochrome c reductase complex 14 kDa protein | protein length=236 NCLIV_024070 537 conserved hypothetical protein | protein length=134 NCLIV_061440 538 hypothetical protein | protein length=210 NCLIV_003580 539 conserved hypothetical protein | protein length=290 NCLIV_046830 540 putative ATP synthase | protein length=202 NCLIV_047040 541 conserved hypothetical protein | protein length=189 NCLIV_063330 542 Ubiquinol-cytochrome c reductase cytochrome c1 subunit, related | protein length=343 NCLIV_022420 543 hypothetical protein | protein length=305 NCLIV_063150 544 Serpin peptidase inhibitor, clade B (Ovalbumin),member 1, like 3, related | protein length=413 NCLIV_010020 545 ubiquinol-cytochrome c reductase iron-sulfur subunit, related | protein length=382 NCLIV_053810 546 Os03g0795800 protein, related | protein length=265 NCLIV_027850 547 unspecified product | protein length=488 NCLIV_042510 548 conserved hypothetical protein | protein length=322 NCLIV_044440 549 hypothetical protein | protein length=430 NCLIV_014040 550 conserved hypothetical protein | protein length=400 NCLIV_004060 551 conserved hypothetical protein | protein length=337 NCLIV_015990 552 hypothetical protein | protein length=97 NCLIV_040600 553 hypothetical protein | protein length=344 NCLIV_018830 554 conserved hypothetical protein | protein length=789 NCLIV_039750 555 hypothetical protein | protein length=502 NCLIV_058180 556 unspecified product | protein length=491 NCLIV_049830 557 conserved hypothetical protein | protein length=583 NCLIV_031860 558 putative serine-threonine phosophatase 2C | protein length=321 NCLIV_045440 559 putative proteasome PCI domain-containing protein | protein length=473 NCLIV_025730 560 conserved hypothetical protein | protein length=770 NCLIV_061030 561 hypothetical protein | protein length=444 NCLIV_063190 562 conserved hypothetical protein | protein length=486 NCLIV_017340 563 hypothetical protein | protein length=1369 NCLIV_027930 564 unspecified product | protein length=615 NCLIV_026180 565 hypothetical protein | protein length=487 NCLIV_019930 566 conserved hypothetical protein | protein length=1312 NCLIV_053940 567 60S acidic ribosomal protein P2, related | protein length=111 NCLIV_029690 568 conserved hypothetical protein | protein length=177 NCLIV_005040 569 conserved hypothetical protein | protein length=160 NCLIV_036130 570 CBR-RSP-4 protein, related | protein length=192 NCLIV_026390 571 putative centrin | protein length=195 NCLIV_008410 572 gamma-aminobutyric acid receptor-associated protein-like 1, related | protein length=124 NCLIV_056910 573 conserved hypothetical protein | protein length=201 NCLIV_068520 574 unspecified product | protein length=180 NCLIV_065750 575 Alpha 2 subunit of 20S proteasome (ISS), related | protein length=258 NCLIV_059980 576 conserved hypothetical protein | protein length=146 NCLIV_066350 577 Os06g0732000 protein, related | protein length=123 NCLIV_035190 578 conserved hypothetical protein | protein length=324 NCLIV_058260 579 hypothetical protein | protein length=85 NCLIV_001660 580 conserved hypothetical protein | protein length=334 NCLIV_028110 581 putative DnaJ protein | protein length=253 NCLIV_026540 582 conserved hypothetical protein | protein length=265 NCLIV_025220 583 conserved hypothetical protein | protein length=204 NCLIV_009030 584 metallophosphoesterase, related | protein length=340 NCLIV_066080 585 conserved hypothetical protein | protein length=229 NCLIV_020140 586 hypothetical protein | protein length=191 NCLIV_026270 587 26S proteasome regulatory subunit S4 like AAA ATpase, related | protein length=375 NCLIV_007900 588 pv1h14125_P, related | protein length=396 NCLIV_011140 589 g118351, related | protein length=536 NCLIV_050620 590 putative lysine decarboxylase domain-containing protein | protein length=395 NCLIV_026210 591 hypothetical protein | protein length=351 NCLIV_042680 592 conserved hypothetical protein | protein length=334 NCLIV_040550 593 conserved hypothetical protein | protein length=217 NCLIV_038410 594 predicted hydrolases or acyltransferases,related | protein length=320 NCLIV 050910 595 conserved hypothetical protein | protein length=646 NCLIV_017990 596 conserved hypothetical protein | protein length=1277 NCLIV_003160 597 nicotinate phosphoribosyltransferase, related | protein length=591 NCLIV_031500 598 hypothetical protein | protein length=765 NCLIV_040860 599 tryptophanyl-tRNAsynthetase,related | protein length=607 NCLIV_044840 600 conserved hypothetical protein | protein length=480 NCLIV_036570 601 YALI0D21604p, related | protein length=945 NCLIV_056950 602 hypothetical protein | protein length=1007 NCLIV_062880 603 conserved hypothetical protein | protein length=805 NCLIV_011400 604 putative ATP-dependent helicase | protein length=1394 NCLIV_037460 605 hypothetical protein | protein length=578 NCLIV_015260 606 conserved hypothetical protein | protein length=784 NCLIV_013460 607 hypothetical protein | protein length=424 NCLIV_049130 608 putative XPG N-terminal domain containing protein | protein length=753 NCLIV_062350 609 Ribosomal protein S27, related | protein length=82 NCLIV_028310 610 conserved hypothetical protein | protein length=143 NCLIV_051110 611 conserved hypothetical protein | protein length=260 NCLIV_028230 612 Proteasome subunit alpha type-7, related | protein length=246 NCLIV_039960 613 hypothetical protein | protein length=310 NCLIV_053890 614 conserved hypothetical protein | protein length=307 NCLIV_036250 615 Asparaginyl-tRNA synthetase, related | protein length=542 NCLIV_010970 616 hypothetical protein | protein length=318 NCLIV_029040 617 putative nucleosome assembly protein | protein length=859 NCLIV_045600 618 putative glycosyl transferase, group 1 domain containing protein | protein length=449 NCLIV_024090 619 putative glutamyl-tRNA synthetase | protein length=775 NCLIV_038570 620 conserved hypothetical protein | protein length=492 NCLIV_032940 621 putative adenosine transporter | protein length=541 NCLIV_003560 622 putative mitochondrial alternative NADH dehydrogenase 1 | protein length=619 NCLIV_004270 623 putative protein kinase | protein length=1118 NCLIV_007330 624 similar to uniprot|P15705 Saccharomyces cerevisiae YOR027w STI1, related | protein length=563 NCLIV_047530 625 conserved hypothetical protein | protein length=628 NCLIV_043180 626 hypothetical protein | protein length=795 NCLIV_043670 627 high mobility group protein, related | protein length=94 NCLIV_024230 628 Zgc:123215, related | protein length=98 NCLIV_054540 629 RAB5C, member RAS oncogene family, related | protein length=185 NCLIV_013360 630 putative plectin | protein length=2378 NCLIV_022270 631 unspecified product | protein length=691 NCLIV_020920 632 conserved hypothetical protein | protein length=2250 NCLIV_044600 633 conserved hypothetical protein | protein length=104 NCLIV_024410 634 10 kDa chaperonin, related | protein length=105 NCLIV_051970 635 putative MIC2-associated protein M2AP | protein length=243 NCLIV_014760 636 conserved hypothetical protein | protein length=169 NCLIV_029060 637 conserved hypothetical protein | protein length=256 NCLIV_058450 638 putative myosin regulatory light chain | protein length=208 NCLIV 054190 639 hypothetical protein | protein length=224 NCLIV_017840 640 conserved hypothetical protein | protein length=119 NCLIV_045430 641 putative DNA-binding protein HU | protein length=221 NCLIV_046030 642 hypothetical protein | protein length=225 NCLIV_056110 643 putative small heat shock protein 211 protein length=194 NCLIV_065830 644 MGC79800 protein, related | protein length=288 NCLIV_003220 645 putative vacuolar ATP synthase subunit h | protein length=481 NCLIV_044120 646 conserved hypothetical protein | protein length=192 NCLIV_064810 647 hypothetical protein | protein length=725 NCLIV_015530 648 conserved hypothetical protein | protein length=366 NCLIV_048050 649 conserved hypothetical protein | protein length=324 NCLIV_020430 650 hypothetical protein | protein length=821 NCLIV_067220 651 conserved hypothetical protein | protein length=407 NCLIV_030070 652 conserved hypothetical protein | protein length=225 NCLIV_064600 653 putative cysteine desulfurase | protein length=811 NCLIV_019750 654 conserved hypothetical protein | protein length=1207 NCLIV_050030 655 hypothetical protein | protein length=475 NCLIV_057710 656 putative ATP synthase epsilon chain | protein length=74 NCLIV_024320 657 conserved hypothetical protein | protein length=75 NCLIV_062710 658 conserved hypothetical protein | protein length=134 NCLIV_009670 659 cold-shock protein, DNA-binding, related | protein length=125 NCLIV_021100 660 unspecified product | protein length=237 NCLIV_052880 661 unspecified product | protein length=193 NCLIV_039480 662 hypothetical protein | protein length=94 NCLIV_003680 663 40s ribosomal protein S28, related | protein length=68 NCLIV_051460 664 conserved hypothetical protein | protein length=112 NCLIV_008890 665 putative tim10/DDP zinc finger domain-containing protein | protein length=91 NCLIV_066190 666 putative caltractin | protein length=170 NCLIV_011960 667 conserved hypothetical protein | protein length=263 NCLIV_055330 668 Fibrillarin superfamily, related | protein length=263 NCLIV_026340 669 hypothetical protein | protein length=177 NCLIV_044100 670 conserved hypothetical protein | protein length=232 NCLIV_018950 671 putative coatomer epsilon subunit | protein length=276 NCLIV_022560 672 Thermosome subunit, related | protein length=539 NCLIV_044950 673 conserved hypothetical protein | protein length=222 NCLIV_027660 674 conserved hypothetical protein | protein length=130 NCLIV_068630 675 conserved hypothetical protein | protein length=195 NCLIV_055370 676 conserved hypothetical protein | protein length=391 NCLIV_046840 677 Acyl-carrier-protein S-malonyltransferase, related | protein length=309 NCLIV_056250 678 hypothetical protein | protein length=499 NCLIV_048600 679 hypothetical protein | protein length=307 NCLIV_032030 680 conserved hypothetical protein | protein length=164 NCLIV_070190 681 Dihydrolipoyl dehydrogenase (EC 1.8.1.4),related | protein length=648 NCLIV_017240 682 conserved hypothetical protein | protein length=293 NCLIV_010610 683 hypothetical protein | protein length=300 NCLIV 007000 684 adp-ribosylation factor 4, related | protein length=183 NCLIV_050630 685 H/ACA ribonucleoprotein complex subunit 2-like protein, related | protein length=131 NCLIV_052070 686 hypothetical protein | protein length=192 NCLIV_023540 687 putative aldo/keto reductase family oxidoreductase | protein length=334 NCLIV_066370 688 hypothetical protein | protein length=402 NCLIV_057460 689 Transketolase central region, related | protein length=412 NCLIV_019780 690 putative KH domain containing protein | protein length=762 NCLIV_026100 691 conserved hypothetical protein | protein length=467 NCLIV_019480 692 proteasome A-type and B-type domain-containing protein | protein length=267 NCLIV_068640 693 putative protein phosphatase 2C | protein length=571 NCLIV_065500 694 conserved hypothetical protein | protein length=311 NCLIV_039280 695 isocitrate dehydrogenase-like protein, related | protein length=419 NCLIV_014330 696 Prolyl oligopeptidase (Precursor),related | protein length=733 NCLIV_010390 697 novel protein (Zgc:77804), related | protein length=460 NCLIV_004810 698 conserved hypothetical protein | protein length=590 NCLIV_035590 699 conserved hypothetical protein | protein length=742 NCLIV_021410 700 conserved hypothetical protein | protein length=438 NCLIV_016420 701 putative pescadillo family protein | protein length=727 NCLIV_039820 702 cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related | protein length=468 NCLIV_003600 703 putative ABC transporter | protein length=833 NCLIV_046890 704 conserved hypothetical protein | protein length=363 NCLIV_067160 705 hypothetical protein | protein length=350 NCLIV_055450 706 putative FUN14 family domain-containing protein | protein length=189 NCLIV_011040 707 putative N-ethylmaleimide-sensitive factor | protein length=730 NCLIV_018560 708 putative ras-GTPase-activating protein binding protein | protein length=848 NCLIV_027230 709 Dihydropteroate synthase, related | protein length=669 NCLIV_024220 710 putative glycerol-3-phosphate dehydrogenase | protein length=642 NCLIV_003890 711 conserved hypothetical protein | protein length=384 NCLIV_065820 712 hypothetical protein | protein length=482 NCLIV_013130 713 conserved hypothetical protein | protein length=1139 NCLIV_060920 714 conserved hypothetical protein | protein length=70 NCLIV_046460 715 conserved hypothetical protein | protein length=92 NCLIV_033810 716 hypothetical protein | protein length=232 NCLIV_069460 717 hypothetical protein | protein length=107 NCLIV_031440 718 60S ribosomal protein L38, related | protein length=84 NCLIV_036510 719 hypothetical protein | protein length=182 NCLIV_025280 720 conserved hypothetical protein | protein length=294 NCLIV_007105 721 unspecified product | protein length=171 NCLIV_017460 722 putative NUDIX hydrolase domain-containing protein | protein length=237 NCLIV_063760 723 hypothetical protein | protein length=408 NCLIV_000280 724 ranbp1 domain containing protein, related | protein length=216 NCLIV_030650 725 putative 26S protease regulatory subunit 6b | protein length=416 NCLIV_024140 726 hypothetical protein | protein length=194 NCLIV 035310 727 putative inhibitor-1 of protein phosphatase type 2A | protein length=289 NCLIV_046540 728 putative oligoendopeptidase F | protein length=630 NCLIV_066770 729 putative seryl-tRNA synthetase | protein length=480 NCLIV_010650 730 conserved hypothetical protein | protein length=298 NCLIV_056830 731 putative 60S ribosomal protein L7a | protein length=177 NCLIV_053590 732 WD-40 repeat protein, related | protein length=802 NCLIV_053640 733 putative peroxidoxin 2 | protein length=224 NCLIV_054910 734 conserved hypothetical protein | protein length=377 NCLIV_058360 735 hypothetical protein | protein length=299 NCLIV_024380 736 conserved hypothetical protein | protein length=543 NCLIV_049400 737 Serine hydroxymethyltransferase,related | protein length=499 NCLIV_067490 738 putative protein phosphatase 2C | protein length=334 NCLIV_023990 739 Acyl carrier protein, related | protein length=183 NCLIV_058420 740 conserved hypothetical protein | protein length=190 NCLIV_001360 741 conserved hypothetical protein | protein length=285 NCLIV_036720 742 CBR-CSN-5 protein, related | protein length=314 NCLIV_037060 743 hypothetical protein | protein length=578 NCLIV_008960 744 hypothetical protein | protein length=499 NCLIV_030470 745 conserved hypothetical protein | protein length=1270 NCLIV_013910 746 Pdcd4-prov protein, related | protein length=504 NCLIV_012500 747 conserved hypothetical protein | protein length=275 NCLIV_029255 748 unspecified product | protein length=136 NCLIV_056440 749 Signal recognition particle GTPase, related | protein length=583 NCLIV_054410 750 Calr protein, related | protein length=599 NCLIV_033275 751 unspecified product | protein length=805 NCLIV_018460 752 conserved hypothetical protein | protein length=414 NCLIV_046970 753 conserved hypothetical protein | protein length=1107 NCLIV_048240 754 hypothetical protein | protein length=939 NCLIV_021570 755 conserved hypothetical protein | protein length=783 NCLIV_027770 756 hypothetical protein | protein length=617 NCLIV_054460 757 conserved hypothetical protein | protein length=599 NCLIV_022690 758 conserved hypothetical protein | protein length=314 NCLIV_046580 759 conserved hypothetical protein | protein length=371 NCLIV_036300 760 conserved hypothetical protein | protein length=141 NCLIV_025600 761 putative calmodulin | protein length=142 NCLIV_008990 762 unspecified product | protein length=294 NCLIV_041870 763 hypothetical protein | protein length=736 NCLIV_060890 764 putative Ras family domain-containing protein | protein length=244 NCLIV_027270 765 putative cell division protein | protein length=959 NCLIV_047010 766 conserved hypothetical protein | protein length=499 NCLIV_044340 767 conserved hypothetical protein | protein length=2073 NCLIV_008900 768 yali0d05697p, related | protein length=51 NCLIV_051960 769 conserved hypothetical protein | protein length=137 NCLIV_058810 770 superoxide dismutase | protein length=201 NCLIV_006170 771 phosphoglycerate mutase, related | protein length=252 NCLIV_054840 772 conserved hypothetical protein | protein length=226 NCLIV 016430 773 conserved hypothetical protein | protein length=264 NCLIV_045530 774 conserved hypothetical protein | protein length=104 NCLIV_007180 775 hypothetical protein | protein length=91 NCLIV_020880 776 hypothetical protein | protein length=133 NCLIV_023130 777 conserved hypothetical protein | protein length=438 NCLIV_003420 778 putative elongation factor ts | protein length=564 NCLIV_048580 779 hypothetical protein | protein length=420 NCLIV_065910 780 conserved hypothetical protein | protein length=309 NCLIV_007120 781 hypothetical protein | protein length=762 NCLIV_004340 782 hypothetical protein | protein length=232 NCLIV_044820 783 conserved hypothetical protein | protein length=271 NCLIV_044850 784 conserved hypothetical protein | protein length=447 NCLIV_054510 785 putative heat shock protein 90 | protein length=975 NCLIV_026520 786 conserved hypothetical protein | protein length=751 NCLIV_006940 787 conserved hypothetical protein | protein length=389 NCLIV_049920 788 conserved hypothetical protein | protein length=914 NCLIV_052000 789 putative DNA replication licensing factor | protein length=1054 NCLIV_032160 790 putative UBA/TS-N domain-containing protein | protein length=757 NCLIV_001930 791 conserved hypothetical protein | protein length=1186 NCLIV_032830 792 hypothetical protein | protein length=1130 NCLIV_032180 793 GK24228, related | protein length=3393 NCLIV_052270 794 conserved hypothetical protein | protein length=105 NCLIV_068620 795 putative Ribosome associated membrane domain-containing protein | protein length=68 NCLIV_025130 796 Translation initiation factor 1A (AeIF-1A),related | protein length=161 NCLIV_049080 797 hypothetical protein | protein length=170 NCLIV_054280 798 conserved hypothetical protein | protein length=84 NCLIV_045490 799 conserved hypothetical protein | protein length=122 NCLIV_038830 800 sm protein, related | protein length=121 NCLIV_031530 801 hypothetical protein | protein length=187 NCLIV_038390 802 hypothetical protein | protein length=112 NCLIV_013780 803 hypothetical protein | protein length=236 NCLIV_054960 804 putative vacuolar ATP synthase subunit f | protein length=127 NCLIV_055190 805 putative myosin light chain TgMLC1 | protein length=137 NCLIV_030910 806 LRRGT00025, related | protein length=84 NCLIV_004570 807 hypothetical protein | protein length=151 NCLIV_003110 808 conserved hypothetical protein | protein length=211 NCLIV_024600 809 hypothetical protein | protein length=158 NCLIV_051040 810 conserved hypothetical protein | protein length=269 NCLIV_059830 811 conserved hypothetical protein | protein length=188 NCLIV_046140 812 conserved hypothetical protein | protein length=213 NCLIV_008650 813 hypothetical protein | protein length=227 NCLIV_014050 814 conserved hypothetical protein | protein length=303 NCLIV_068650 815 putative endoplasmic reticulum retention receptor | protein length=224 NCLIV_065410 816 putative ctr copper transporter domain-containing protein | protein length=239 NCLIV_037400 817 putative la domain-containing protein | protein length=559 NCLIV_030630 818 p25-alpha family protein, related | protein length=169 NCLIV_046900 819 hypothetical protein | protein length=253 NCLIV_059790 820 putative proteasome subunit alpha type 3 | protein length=260 NCLIV_010050 821 srs domain-containing protein | protein length=459 NCLIV_066820 822 putative proteasome activator subunit | protein length=267 NCLIV_061340 823 hypothetical protein | protein length=187 NCLIV_063610 824 conserved hypothetical protein | protein length=382 NCLIV_003990 825 conserved hypothetical protein | protein length=298 NCLIV_037540 826 YOR039Wp-like protein, related | protein length=320 NCLIV_028870 827 Peptidylprolyl isomerase D (Cyclophilin D),related | protein length=529 NCLIV_058310 828 putative vacuolar ATP synthase subunit c | protein length=409 NCLIV_026040 829 putative structure specific recognition protein I | protein length=538 NCLIV_024990 830 conserved hypothetical protein | protein length=112 NCLIV_046390 831 hypothetical protein | protein length=221 NCLIV_049110 832 hypothetical protein | protein length=354 NCLIV_031030 833 conserved hypothetical protein | protein length=379 NCLIV_043070 834 hypothetical protein | protein length=244 NCLIV_011840 835 hypothetical protein | protein length=285 NCLIV_060330 836 putative molybdopterin cofactor sulfurase | protein length=756 NCLIV_053970 837 conserved hypothetical protein | protein length=430 NCLIV_034650 838 conserved hypothetical protein | protein length=306 NCLIV_045860 839 hypothetical protein | protein length=450 NCLIV_029800 840 conserved hypothetical protein | protein length=155 NCLIV_045190 841 Proteophosphoglycan ppg1, related | protein length=1357 NCLIV_005550 842 hypothetical protein | protein length=502 NCLIV_052950 843 SRS domain-containing protein | protein length=366 NCLIV_065640 844 putative Rhoptry kinase family protein, truncated (incomplete catalytic triad) | protein length=538 NCLIV_033030 845 conserved hypothetical protein | protein length=1264 NCLIV_046620 846 Plasmodium vivax PV1H14060_P, related | protein length=785 NCLIV_069400 847 hypothetical protein, conserved | protein length=208 NCLIV_009170 848 proteasome (Prosome, macropain) subunit, beta type, 1, related I protein length=191 NCLIV_022080 849 hypothetical protein | protein length=212 NCLIV_062220 850 Glutaminyl-tRNA synthetase,related | protein length=402 NCLIV_049150 851 conserved hypothetical protein | protein length=1134 NCLIV_056560 852 putative DEAD/DEAH box helicase | protein length=694 NCLIV_045350 853 conserved hypothetical protein | protein length=1000 NCLIV_024360 854 hypothetical protein | protein length=763 NCLIV_0155 855 alpha/beta hydrolase fold domain containing protein | protein length=744 NCLIV_033090 856 putative rhoGAP protein | protein length=525 NCLIV_002660 857 hypothetical protein | protein length=262 NCLIV_067260 858 Diaminopimelate decarboxylase protein, related | protein length=563 NCLIV_032250 859 conserved hypothetical protein | protein length=307 NCLIV_016220 860 unspecified product | protein length=574 NCLIV_053680 861 hypothetical protein | protein length=665 NCLIV 035750 862 putative vacuolar protein sorting-associated protein | protein length=658 NCLIV_040040 863 grpe protein homolog, related | protein length=361 NCLIV_004680 864 conserved hypothetical protein | protein length=703 NCLIV_014450 865 Phosphoglucomutase 2, related | protein length=719 NCLIV_016520 866 hypothetical protein | protein length=779 NCLIV_013840 867 hypothetical protein | protein length=792 NCLIV_062610 868 Zdhhc9 protein, related protein length=391 NCLIV_008860 869 hypothetical protein | protein length=415 NCLIV_060110 870 conserved hypothetical protein | protein length=895 NCLIV_063620 871 conserved hypothetical protein | protein length=450 NCLIV_051920 872 conserved hypothetical protein | protein length=944 NCLIV_060990 873 hypothetical protein | protein length=918 NCLIV_063490 874 conserved hypothetical protein | protein length=520 NCLIV_068580 875 hypothetical protein | protein length=603 NCLIV_065770 876 putative nuclear cap binding protein | protein length=1217 NCLIV_051440 877 putative WD-40 repeat protein | protein length=1433 NCLIV_047350 878 conserved hypothetical protein | protein length=713 NCLIV_060640 879 putative Gpi16 subunit, GPI transamidase domain-containing protein | protein length=717 NCLIV_004700 880 conserved hypothetical protein | protein length=1670 NCLIV_060900 881 conserved hypothetical protein | protein length=1938 NCLIV_061290 882 putative DEAD/DEAH box RNA helicase | protein length=969 NCLIV_043870 883 conserved hypothetical protein | protein length=1049 NCLIV_047370 884 conserved hypothetical protein | protein length=2085 NCLIV_055820 885 hypothetical protein | protein length=1641 NCLIV_003410 886 putative HECT-domain (ubiquitin-transferase) containing protein| protein length=11957 NCLIV_003470 887 putative thrombospondin type 1 domain-containing protein| protein length=822 NCLIV_006290 888 conserved hypothetical protein| protein length=4189 NCLIV_0153 889 longevity-assurance (LAG1) domain-containing protein| protein length=4721 NCLIV_015950 890 conserved hypothetical protein| protein length=1421 NCLIV_019520 891 MGC83258 protein, related| protein length=16227 NCLIV_020980 892 hypothetical protein | protein length=1988 NCLIV_026590 893 putative DEAD/DEAH box helicase | protein length=1808 NCLIV_032810 894 conserved hypothetical protein | protein length=1531 NCLIV_0376 1022 elongation factor Tu GTP-binding domain-containing protein | protein length=1737 NCLIV_038990 895 conserved hypothetical protein | protein length=522 NCLIV_040650 896 conserved hypothetical protein | protein length=2379 NCLIV_042610 897 conserved hypothetical protein | protein length=2636 NCLIV_045300 898 Chloroquine resistance marker protein, related | protein length=4004 NCLIV_046940 899 putative PWWP domain-containing protein | protein length=2083 NCLIV_048380 900 conserved hypothetical protein | protein length=2277 NCLIV_056570 901 Collagen alpha-1(III) chain (Precursor), related | protein length=2814 NCLIV_057020 902 conserved hypothetical protein | protein length=1546 NCLIV_058800 903 hypothetical protein | protein length=962 NCLIV 059730 904 conserved hypothetical protein | protein length=724 NCLIV_059960 905 conserved hypothetical protein | protein length=5715 NCLIV_064260 906 putative WD domain-containing protein | protein length=3128 NCLIV_064490 907 putative phosphatidylinositol 3-and 4-kinase domain-containing protein | protein length=1726 NCLIV_070170 908 hypothetical protein | protein length=8792 NCLIV_001280 909 putative ribokinase | protein length=440 NCLIV_001290 910 conserved hypothetical protein | protein length=1221 NCLIV_001550 911 putative ribonucleoside-diphosphate reductase, large subunit | protein length=886 NCLIV_001770 912 putative DNAK family domain containing protein | protein length=802 NCLIV_001890 913 hypothetical protein | protein length=975 NCLIV_002680 914 agap001651-PA, related | protein length=521 NCLIV_004200 915 hypothetical protein | protein length=1734 NCLIV_004250 916 putative nuclear RNA binding protein protein | length=373 NCLIV_005500 917 conserved hypothetical protein | protein length=1136 NCLIV_005770 918 hypothetical protein | protein length=1153 NCLIV_005860 919 IMP-specific 5'-nucleotidase, related | protein length=656 NCLIV_006150 920 tRNAbinding domain containing protein, related | protein length=434 NCLIV_006620 921 trehalose-6-phosphate synthase of likely plant origin, related | protein length=1215 NCLIV_006850 922 unspecified product | protein length=2418 NCLIV_007580 923 hypothetical protein | protein length=1601 NCLIV_007730 924 valyl-tRNAsynthetase, mitochondrial, related | protein length=1057 NCLIV_007860 925 hypothetical protein | protein length=570 NCLIV_008100 926 putative IMPortin-alpha re-exporter | protein length=1054 NCLIV_009300 927 gk17769, related | protein length=619 NCLIV_010370 928 ubiquitin carrier protein, related | protein length=147 NCLIV_010960 929 putative phosphoglucomutase | protein length=647 NCLIV_011120 930 malate dehydrogenase, related | protein length=316 NCLIV_011740 931 conserved hypothetical protein | protein length=285 NCLIV_011830 932 conserved hypothetical protein | protein length=191 NCLIV_012700 933 putative TCP-1/cpn60 family chaperonin | protein length=557 NCLIV_012860 934 Leucyl-tRNA synthetase 2, related | protein length=1160 NCLIV_015460 935 hypothetical protein | protein length=238 NCLIV_016000 936 conserved hypothetical protein | protein length=1393 NCLIV_016150 937 Serine--pyruvate transaminase, related | protein length=381 NCLIV_017040 938 Phosphofructokinase, related | protein length=1400 NCLIV_017470 939 Proteasome subunit alpha type,related | protein length=296 NCLIV_018300 940 HIT family protein, related | protein length=153 NCLIV_019960 941 putative lysyl-tRNA synthetase | protein length=598 NCLIV_020310 942 putative fructose-1,6-bisphosphatase | protein length=387 NCLIV_021260 943 hypothetical protein | protein length=567 NCLIV_022000 944 putative para-aminobenzoate synthase | protein length=716 NCLIV_022400 945 hypothetical protein | protein length=549 NCLIV_022550 946 GK15875, related | protein length=456 NCLIV_028820 947 hypothetical protein | protein length=587 NCLIV 028830 948 Glucose-6-phosphate isomerase,related | protein length=481 NCLIV_029720 949 putative eukaryotic translation intiation factor | protein length=860 NCLIV_029970 950 tRNA synthetase Gly, related | protein length=716 NCLIV_030120 951 putative importin beta-3 subunit | protein length=1166 NCLIV_030290 952 putative transaldolase | protein length=377 NCLIV_030480 953 hypothetical protein | protein length=414 NCLIV_031320 954 conserved hypothetical protein | protein length=1583 NCLIV_031560 955 Arsenite-activated ATPase ArsA,related | protein length=333 NCLIV_031730 956 putative translational activator | protein length=3415 NCLIV_031750 957 putative importin | protein length=1199 NCLIV_032130 958 conserved hypothetical protein | protein length=961 NCLIV_032240 959 Catalase (EC 1.11.1.6), related | protein length=516 NCLIV_032320 960 hypothetical protein | protein length=641 NCLIV_032950 961 putative deoxyuridine 5'-triphosphate nucleotidohydrolase | protein length=188 NCLIV_033140 962 hypothetical protein | protein length=125 NCLIV_033830 963 hypothetical protein | protein length=380 NCLIV_034160 964 Glutamine synthetase, related | protein length=455 NCLIV_039940 965 hypothetical protein | protein length=395 NCLIV_040730 966 ypothetical protein | protein length=750 NCLIV_041690 967 ubiquitin carboxyl-terminal hydrolase, related | protein length=2325 NCLIV_041850 968 putative Hsp20/alpha crystallin domain-containing protein | protein length=271 NCLIV_041900 969 phosphoenolpyruvate carboxykinase (ATP), related | protein length=582 NCLIV_042265 970 hypothetical protein | protein length=483 NCLIV_042370 971 hypothetical protein | protein length=246 NCLIV_042400 972 macrophage migration inhibitory factor, related | protein length=116 NCLIV_042500 973 ubiquitin-activating enzyme E1, related | protein length=1100 NCLIV_043140 974 putative aspartate carbamoyltransferase | protein length=363 NCLIV_043320 975 rna recognition motif (RRM)-containing protein,related | protein length=555 NCLIV_044270 976 hypothetical protein | protein length=723 NCLIV_045170 977 hypothetical protein | protein length=272 NCLIV_045980 978 conserved hypothetical protein | protein length=170 NCLIV_048530 979 GK19179, related | protein length=2878 NCLIV_048670 980 cDNA FLJ55447, highly similar to ATP-citrate synthase, related | protein length=1295 NCLIV_048930 981 hypothetical protein | protein length=1146 NCLIV_050000 982 putative deoxyhypusine synthase, related | protein length=429 NCLIV_051000 983 Ethylene-inducible protein hever, related | protein length=307 NCLIV_051530 984 hypothetical protein | protein length=258 NCLIV_051590 985 putative GTP binding protein | protein length=396 NCLIV_051620 986 putative 4'-phosphopantetheinyl transferase | protein length=350 NCLIV_052340 987 hypothetical protein | protein length=230 NCLIV_052870 988 conserved hypothetical protein | protein length=2579 NCLIV_052980 989 hypothetical protein | protein length=392 NCLIV_053190 990 hypothetical protein | protein length=674 NCLIV_053860 991 MGC84926 protein, related | protein length=528 NCLIV_054150 992 Ubiquitin-conjugating enzyme, related | protein length=140 NCLIV_054700 993 putative uridine phosphorylase | protein length=302 NCLIV_055070 994 Ubiquitin carboxyl-terminal hydrolase, related | protein length=627 NCLIV_055170 995 DnaJ domain containing protein, related | protein length=426 NCLIV_055230 996 putative serine/threonine protein phosphatase | protein length=475 NCLIV_055660 997 conserved hypothetical protein | protein length=377 NCLIV_055800 998 Serine/threonine protein phosphatase 5, related | protein length=598 NCLIV_056020 999 hypothetical protein | protein length=248 NCLIV_056140 1000 conserved hypothetical protein | protein length=2723 NCLIV_057250 1001 conserved hypothetical protein | protein length=215 NCLIV_058000 1002 putative alanine dehydrogenase | protein length=390 NCLIV_058010 1003 conserved hypothetical protein | protein length=774 NCLIV_059620 1004 conserved hypothetical protein | protein length=400 NCLIV_059920 1005 putative eukaryotic initiation factor-2B gamma subunit | protein length=528 NCLIV_060470 1006 hypothetical protein | protein length=671 NCLIV_060600 1007 6-phosphogluconate dehydrogenase, decarboxylating, related | protein length=505 NCLIV_061050 1008 hypothetical protein | protein length=1034 NCLIV_061600 1009 hypothetical protein | protein length=469 NCLIV_061720 1010 hypothetical protein | protein length=3385 NCLIV_062230 1011 Glutaminyl-tRNA synthetase,related | protein length=525 NCLIV_063380 1012 hypothetical protein | protein length=439 NCLIV_065240 1013 Fructose-1 6-biphosphatase, related | protein length=349 NCLIV_065280 1014 Proliferating cell nuclear antigen, related | protein length=321 NCLIV_065390 1015 Bifunctional dihydrofolate reductase-thymidylate synthase, related | protein length=690 NCLIV_065690 1016 hypothetical protein | protein length=1117 NCLIV_066410 1017 GG10762, related | protein length=363 NCLIV_066760 1018 Translationally-controlled tumor protein,related | protein length=171 NCLIV_066920 1019 hypothetical protein | protein length=430 NCLIV_067980 1020 Proteasome subunit alpha type,related | protein length=247 NCLIV_069700 1021 hypothetical protein, conserved | protein length=2310 <1> Accession number for the identified protein in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015. <2> Protein description in ToxoDB database (ToxoDB-13.0_NcaninumLIV_AnnotatedProteins; 7122 sequences; Date 09 February 2015) 4. A method for producing a composition comprising the following steps: a. Providing Neospora cells in a hypertonic solution; b. Centrifuging said solution obtained in step (a) under conditions suitable for separating the soluble fraction (supernatant) and insoluble fraction (precipitate), wherein the centrifugation takes place at 8.000-15.000xg, during 40-90 min and at a temperature of 1-10° C; c. Recovering the precipitate from step (b); d. Mixing said precipitate with a non-ionic surfactant; and e. Homogenising the mixture obtained after step (d). 5. The method according to claim 4, wherein the Neospora cells belong to the species Neospora caninum. 6. The method according to any one of claims 4 to 5, wherein the hypertonic solution comprises sucrose, and/or sorbitol, and/or mannitol. 7. The method according to any one of claims 4 to 6, wherein the centrifugation takes place at 8.000-15.000xg, during 60 min at about 4 °C. 8. The method according to any one of claims 4 to 7, wherein the non-ionic surfactant is selected from the group consisting of: Polysorbate 80, Triton X-114, Triton X-100 and Tween 20. 9. A pharmaceutical composition comprising the composition according to any one of claims 1 to 3, wherein the pharmaceutical composition further comprises one or more excipients and/or one or more pharmaceutically acceptable carriers or diluents, wherein said pharmaceutical composition is a vaccine, wherein the vaccine comprises an adjuvant, and wherein the adjuvant is a saponin. 10. The vaccine according to claim 10, wherein the saponin adjuvant is QuilA<®>. 11. The pharmaceutical composition according to claim 9 and/or the vaccine according to claim 10, wherein said pharmaceutical composition comprises an amount of from 0.0001% to 0.5% w/v of the composition as defined in any one of claims 1 to 3. 12. The composition according to any one of claims 1 to 3, the pharmaceutical composition according to any one of claims 9 or 11 and/or the vaccine according to any one of claims 10 to 11 for use as a medicament. 13. The composition according to any one of claims 1 to 3, the pharmaceutical composition according to any one of claims 9 or 11 and/or the vaccine according to any one of claims 10 to 11 for use in a method of therapeutic treatment and/or prophylactic treatment of infections caused by Neospora. 14. The composition according to any one of claims 1 to 3, the pharmaceutical composition according to any one of claims 9 or 11 and/or the vaccine according to any one of claims 10 to 11, for use according to any one of claims 12 to 13, wherein the composition and/or the pharmaceutical composition and/or the vaccine is administered to a mammal. 15. The composition according to any one of claims 1 to 3, the pharmaceutical composition according to any one of claims 9 or 11 and/or the vaccine according to any one of claims 10 to 11, for use according to any one of claims 12 to 14, wherein the composition and/or the pharmaceutical composition and/or the vaccine is administered to a mammal at least two times in an amount of 0.001-10 µg of the composition as defined in any one of claims 1 to 3 per kg of the individual (mammal) to which the pharmaceutical composition and/or the vaccine is administrated, with at least 14-21 days between each of the administrations, and/or wherein the composition and/or the pharmaceutical composition and/or the vaccine is administered intranasally, intradermally, subcutaneously, by aerosol, intramuscularly, wing web or eye-drop administration.

Etiquetas

Inventores
Regidor Cerrillo JavierArranz Solís DavidCollantes Fernández EstherÁlvarez García GemaOrtega Mora Luis MiguelDavid Arranz SolísEsther Collantes FernándezGema Álvares GarcíaJavier Regidor CerrilloLuis Miguel Ortega MoraArranz Solis DavidCollantes Fernandez EstherAlvarez Garcia GemaGema Álvarez García
Solicitantes
Universidad Complutense de Madrid
Clasificacion ipc
A61K 39/ 002 A IC07K 14/ 435 A IC07K 14/ 44 A IA61K 39/ 00 A IA61K 39/ 012 A IA61P 33/ 02 A IC12N 1/ 10 A I
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