The present invention relates to compounds of formula (I), in addition to the use thereof for the treatment and/or prevention of diseases caused by protozoa, especially those belonging to the genus Leishmania or Trypanosoma. The present invention likewise relates to pharmaceutical compositions comprising said compounds. (I)
1. A compound of general formula (I) <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0020" /> or any of the pharmaceutically acceptable isomers, solvates or salts thereof, wherein: R<1> and R<2> are independently selected from H, O'Pr and halogen; R<3> and R<3>' are independently selected from <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0021" /> Z is selected from <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0022" /> X and Y are independently selected from CH and N, for use thereof as a medicament. 2. The compound for use, according to claim 1, wherein R<1> and R<2> are the same. 3. The compound for use, according to claim 2, wherein R<1> and R<2> are H. 4. The compound for use, according to claim 2, wherein R<1> and R<2> are Cl. 5. The compound for use, according to claim 2, wherein R<1> and R<2> are O'Pr. 6. The compound for use, according to claim 2, wherein R<1> and R<2> are F. 7. The compound for use, according to any of the preceding claims, wherein X and Y are CH. 8. The compound for use, according to any of the preceding claims 1 to 6, wherein X is CH and Y is N. 9. The compound for use, according to any of the preceding claims 1 to 6, wherein X and Y are both N. 10. The compound for use, according to any of the preceding claims, wherein Z is <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0023" /> 11. The compound for use, according to any of the preceding claims, wherein R<3> and R<3>' are the same and are : <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0024" /> 12. The compound for use, according to claim 1, wherein the compound is selected from: - 4-(picolinimidamido)-N-(4-(picolinimidamido)phenyl)benzamide (3a) - 5-(picolinimidamido)-N-(5-(picolinimidamido)pyridin-2-yl)picolinamide (3b) - 3-chloro-N-(2-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3c) - 3-chloro-N-(3-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3d) - 2-chloro-N-(2-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3e) - 2-chloro-N-(3-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3f) - 2-isopropoxy-N-(2-isopropoxy-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3g) - 4-(picolinimidamido)-N-(5-(picolinimidamido)pyridin-2-yl)benzamide (3h) - 3-fluoro-N-(2-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3i) - 3-fluoro-N-(3-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3j) - 2-fluoro-N-(2-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3k) - 2-fluoro-N-(3-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3l) - N,N"-(ethane-1,2-diylbis(4,1-phenylene))dipicolinimidamide (17) - N,N"-((carbonylbis(azanediyl))bis(4,1-phenylene))dipicolinimidamide (18) - 4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)-N-(4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)benzamide (1a) - 5-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)-N-(5-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)pyridin-2-il)picolinamide (1b) - 3-chloro-N-(2-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1c) - 3-chloro-N-(3-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1d) - 2-chloro-N-(2-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1e) - 2-chloro-N-(3-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1f) - -4,4'-(ethane-1,2-diyl)bis(N-(1H-benzo[d]imidazol-2(3H)-ylidene)aniline(13) - 1,3-bis(4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)urea (14). 13. A compound of general formula (I) described in any of claims 1 to 12, for use in the prevention and/or treatment of diseases caused by protozoan parasites. 14. The compound for use, according to claim 13, wherein the protozoan parasites are of the genera Leishmania or Trypanosoma. 15. The compound for use, according to claim 14, wherein protozoan parasites of the genera Leishmania or Trypanosoma are of the species L. aethiopica, L. amazonensis, L. arabica, L. archibaldi, L. aristedesi, L. braziliensis, L. chagasi (syn. L. infantum), L. colombiensis, L. deanei, L. donovani, L. enriettii, L. equatorensis, L. forattinii, L. gamhami, L. gerbili, L. guyanensis, L. herreri, L. hertigi, L. infantum, L. killicki, L. lainsoni, L. major, L. mexicana, L. naiffi, L. panamensis, L. peruviana, L. pifanoi, L. shawi, L. tarentolae, L. tropica, L. turanica, L. venezuelensis, T. brucei, T. cruzi, T. congolense, T. equinum, T. equiperdum, T. evansi or T. vivax. 16. The compound for use, according to claim 15, wherein the protozoan parasites are of the species T. brucei, T. cruzi and/or L. donovani. 17. The compound for use, according to any of the preceding claims 13 to 16, wherein the disease is selected from leishmaniasis, human African trypanosomiasis, animal tripanosomiasis or American tripanosomiasis. 18. A compound of general formula (I) <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0025" /> or any of the pharmaceutically acceptable isomers, solvates or salts thereof, wherein: R<1>, R<2>, R<3>, R<3>', Z, X and Y are described according to any of claims 1 to 10, and with the condition that the compound is not: <img class="EMIRef" id="23d93c9c-05de-4af8-ba35-8b56954219b3-ib0026" /> nor a tautomer thereof. 19. The compound according to claim 18, wherein the compound is selected from: - 4-(picolinimidamido)-N-(4-(picolinimidamido)phenyl)benzamide (3a) - 5-(picolinimidamido)-N-(5-(picolinimidamido)pyridin-2-yl)picolinamide (3b) - 3-chloro-N (2-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3c) - 3-chloro-N-(3-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3d) - 2-chloro-N-(2-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3e) - 2-chloro-N-(3-chloro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3f) - 2-isopropoxy-N-(2-isopropoxy-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide (3g) - 4-(picolinimidamido)-N-(5-(picolinimidamido)pyridin-2-yl)benzamide (3h) - 3-fluoro-N-(2-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3i) - 3-fluoro-N-(3-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3j) - 2-fluoro-N-(2-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3k) - 2-fluoro-N-(3-fluoro-4-(picolinimidamido)phenyl)-4-(picolinimidamido)benzamide di-trifluoroacetate (3l) - N,N"-(ethane-1,2-diyI bis(4,1 -phenylene))dipicolinimidamide (17) - N,N"-((carbonylbis(azanediyl))bis(4,1-phenylene))dipicolinimidamide (18) - 4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)-N-(4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)benzamide (1a) - 5-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)-N-(5-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)pyridin-2-il)picolinamide (1b) - 3-chloro-N-(2-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1c) - 3-chloro-N-(3-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1d) - 2-chloro-N-(2-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1e) - 2-chloro-N-(3-chloro-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)-4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)benzamide (1f) - 1,3-bis(4-((1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)amino)phenyl)urea (14). 20. A pharmaceutical composition comprising a compound of general formula (I) described according to any of claims 18 to 19, together with a pharmaceutically acceptable excipient, adjuvant and/or carrier. 21. The pharmaceutical composition, according to claim 20, which further comprises another antiparasitic agent.