madrid2i

[0001] The present invention describes the preparation of ordered mesoporous silica materials, capable of promoting bone development, and the use thereof as a release system for releasing a combination of antibiotics for treating bone infections locally and effectively. [0002] The present invention therefore proposes the use of these materials for the treatment of osteomyelitis, since their high porosity and large specific surface area allows adsorbing a large amount of antibiotics for subsequently releasing them in a modulated manner, depending on patient's requirements. The present invention proposes the use of bioceramic SBA-15 for the adsorption of a combination of three antibiotics, the antimicrobial activity of which has been widely recognized: vancomycin, linezolid and rifampicin.

Datos clave

CategoríaInvención

Índice de la ficha

Updated at: 05/11/2026
Numero publicacion: EP.2719400.A2
Fecha publicacion: 16/04/2014
Anio publicacion: 2014
Numero solicitud: EP20120797636

En detalle

Reivindicaciones

1. Antibiotic-containing bioceramic material with controlled-release of bioactive agents,characterized in that it comprises an ordered mesoporous silica material, one or several antibiotics suitable for the treatment of osteomyelitis and, optionally, a bacterial quorum sensing inhibiting peptide. 2. Antibiotic-containing bioceramic material with controlled-release of bioactive agents according to claim 1, where the ordered silica material is SBA-15. 3. Antibiotic-containing bioceramic material with controlled-release of bioactive agents according to the preceding claims, where the antibiotic is rifampicin, vancomycin, linezolid or a combination thereof. 4. Antibiotic-containing bioceramic material with controlled-release of bioactive agents, where the inhibiting peptide is RIP (RNA Inhibiting Peptide). 5. Use of the bioceramic material defined in claims 1-4 in the elaboration of a bone implant for the treatment of osteomyelitis.

Etiquetas

Inventores

Vallet Regi, MariaVallet Regi MariaManzano Garcia MiguelManzano Garcia,MiguelEsteban Moreno, JaimeEsteban Moreno JaimeMolina Manso, DianaMolina Manso DianaGomez Barrena EnriqueGomez Barrena, EnriqueManzano Garcia, Miguel

Solicitantes

Universidad Complutense de MadridFundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz

Clasificacion ipc

A61F 2/ 28 A IA61L 27/ 10 A IA61L 27/ 54 A IA61L 27/ 56 A IA61L 27/ 58 A IA61P 19/ 00 A IC01B 37/ 00 A I